[pursuant to NOT-AG-18-008 submission instructions, this Supplement Abstract reflects the relevance of the proposed research to AD/ADRD and so is updated from the parent-grant Abstract. However, the scope of the parent-grant is unchanged as funded. In the Supplement Abstract, additions from the parent grant abstract in RED] Abstract The BRAIN initiative aiming to revolutionize understanding of the brain requires ?improvement of existing non-invasive neuromodulation? (RFA-MH-16-810). Arguably no existing technique in humans has generated more interest than transcranial Direct Current Stimulation (tDCS). tDCS applications span Alzheimer's Disease and its related Dementias (AD/ADRD). For the value of ongoing and future to be maximized, computational models must be adapted to tDCS in older individuals. Computational models of tDCS predict brain current-flow in individual subjects, and support the development of targeted montages. In older adults with brain atrophies highly conducting cerebrospinal fluid fills the void and significantly alters current flow in the brain. Through three innovations, this proposal removes barriers limiting access to computational models by tDCS researcher for this population. First, a decade of technical innovation in automated image segmentation and high-throughput current-flow modeling will be enhanced and encoded in cloud- enabled open-source. Through this supplement, we will further enhance reliability in modeling older adults. Second, state-of-the-art MRI mapping of tDCS current distribution will validate and refine model methods. Through this supplement, we will empirically validate altered current flow in adults with brain atrophy. Third, stand-alone and web-based modeling software will be deployed, with computationally demanding steps implemented on servers. Ongoing and future work testing tDCS for AD/ADRD will directly benefit. Directly responsive to the parent RFA, the outcome of this proposal is a toolbox for the optimization of tDCS spatial precision to enhance the rigor of tDCS research aimed at understanding the brain and treating disease. Directly responsive to the supplement RFA, the enhancements described here will stimulate additional activity leading to progress in AD/ADRD treatments using tDCS. While the supplement focuses on AD/ADRD, the work proposed is within the scope of the active award.

Public Health Relevance

(from original submission) Non-invasive electrical brain stimulation can be a powerful tool to test the role of a specific brain region in cognition, behavior, and disease. We will develop a computer program that allows any brain researcher to upload a brain scan of a subject and then design a brain stimulation experiment that targets a specific brain region.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
3R01MH111896-03S1
Application #
9719160
Study Section
Special Emphasis Panel (ZMH1)
Program Officer
Friedman, Fred K
Project Start
2016-09-26
Project End
2019-06-30
Budget Start
2018-08-27
Budget End
2019-06-30
Support Year
3
Fiscal Year
2018
Total Cost
Indirect Cost
Name
City College of New York
Department
Engineering (All Types)
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
603503991
City
New York
State
NY
Country
United States
Zip Code
10036
Chhatbar, Pratik Y; Kautz, Steven A; Takacs, Istvan et al. (2018) Evidence of transcranial direct current stimulation-generated electric fields at subthalamic level in human brain in vivo. Brain Stimul 11:727-733
Charvet, Leigh E; Dobbs, Bryan; Shaw, Michael T et al. (2018) Remotely supervised transcranial direct current stimulation for the treatment of fatigue in multiple sclerosis: Results from a randomized, sham-controlled trial. Mult Scler 24:1760-1769
Mourdoukoutas, Antonios P; Truong, Dennis Q; Adair, Devin K et al. (2018) High-Resolution Multi-Scale Computational Model for Non-Invasive Cervical Vagus Nerve Stimulation. Neuromodulation 21:261-268
Charvet, Leigh; Shaw, Michael; Dobbs, Bryan et al. (2018) Remotely Supervised Transcranial Direct Current Stimulation Increases the Benefit of At-Home Cognitive Training in Multiple Sclerosis. Neuromodulation 21:383-389
Esmaeilpour, Zeinab; Marangolo, Paola; Hampstead, Benjamin M et al. (2018) Incomplete evidence that increasing current intensity of tDCS boosts outcomes. Brain Stimul 11:310-321
Leite, Jorge; Gonçalves, Óscar F; Pereira, Patrícia et al. (2018) The differential effects of unihemispheric and bihemispheric tDCS over the inferior frontal gyrus on proactive control. Neurosci Res 130:39-46
Chakraborty, Darpan; Truong, Dennis Q; Bikson, Marom et al. (2018) Neuromodulation of Axon Terminals. Cereb Cortex 28:2786-2794
Jackson, Mark P; Bikson, Marom; Liebetanz, David et al. (2017) How to consider animal data in tDCS safety standards. Brain Stimul 10:1141-1142
Jackson, Mark P; Truong, Dennis; Brownlow, Milene L et al. (2017) Safety parameter considerations of anodal transcranial Direct Current Stimulation in rats. Brain Behav Immun 64:152-161
Jackson, Mark P; Bikson, Marom; Liebetanz, David et al. (2017) Toward comprehensive tDCS safety standards. Brain Behav Immun 66:413

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