Adolescence is a developmental stage of physical and psychological maturation that is preceded by and includes changes in sleep. It is also a critical period associated with the onset of psychiatric disorders. However, how a child's sleeping brain predicts the development of psychopathology, including neurocognitive and emotional disorders, later on during adolescence remains poorly understood. In order to bridge this gap, we have collected preliminary data that suggests that changes in brain activity during specific sleep periods and stages of sleep are significantly associated with sleep disorders and executive deficits and internalizing symptoms in children, adolescents and young adults. Importantly, this project will expand on our previous work in this area by giving us the opportunity to conduct longitudinal analyses of the Penn State Child Cohort, a population-based sample of 700 young children, who participated in a comprehensive sleep study, and neurocognitive, behavioral and medical assessment. This study will provide us with novel findings on the association of changes in brain activity during sleep, typically neglected in routine clinical practice, with cognitive and emotional processes that are present across multiple psychiatric disorders. It will also enable us to test the novel hypothesis that changes in brain activity during sleep are associated with increased risk for the development of neurocognitive disorders and psychopathology during this important transitional period.

Public Health Relevance

Adolescence is a transitional stage of physical and psychological development that includes maturational changes in sleep. It is also a critical period for the onset of sleep and psychiatric disorders persisting into adulthood. Our study targets for the first time whether developmental brain changes during sleep place young children at increased risk for cognitive deficits and emotional problems in the transition to adolescence.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH118308-01A1
Application #
9761613
Study Section
Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section (NPAS)
Program Officer
Zehr, Julia L
Project Start
2019-04-17
Project End
2022-01-31
Budget Start
2019-04-17
Budget End
2020-01-31
Support Year
1
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033