More than 20 million U.S. women of the Baby Boomer cohort will make th transition to menopause between 2000 and 2010. Despite women's increasing search for information about menopause, little is known about the natural history of the menopausal transition, those years before menopause. Our recent description of an early, middle and late stage of the menopausal transition allows us to continue this 10-year longitudinal study of a group of midlife women with a focus on hormone changes, perceived stress, physiologic stress arousal, symptoms, and depressed mood during three stages of the menopausal transition. An additional focus will be to assess the effects of genetic polymorphisms of the estrogen receptor gene (ESR1 PvuII) and estrogen metabolic genes (CYP17, CYP19, EDH17B2, CYP1A1, CYP1b1 enzymes) on estradiol and estrone levels, age of onset of middle and late transition and menopause, and menstrual bleeding. It is estimated that by the end of this proposed 5-year study the majority of women would have reached late transition or be menopausal. Data collection will involve obtaining a single blood sample for estradiol, a single buccal cell scraping for DNA analysis, four urine samples a year assayed for estrone, FSH, testosterone, cortisol and catecholamines, four 3-day symptom diaries per year, questionnaires, and yearly menstrual calendar. T he results of this study will help inform women and clinicians about normal changes associated with three stages of the menopausal transition and about genetic factors influencing estrogen levels, age of onset of stages of the menopausal transition and menopause and menstrual bleeding.

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Research Project (R01)
Project #
5R01NR004141-09
Application #
6834616
Study Section
Nursing Research Study Section (NURS)
Program Officer
Bryan, Yvonne E
Project Start
1996-09-01
Project End
2006-12-31
Budget Start
2005-01-01
Budget End
2005-12-31
Support Year
9
Fiscal Year
2005
Total Cost
$398,529
Indirect Cost
Name
University of Washington
Department
Other Health Professions
Type
Schools of Nursing
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Woods, Nancy Fugate; Cray, Lori A; Mitchell, Ellen Sullivan et al. (2018) Polymorphisms in Estrogen Synthesis Genes and Symptom Clusters During the Menopausal Transition and Early Postmenopause: Observations From the Seattle Midlife Women's Health Study. Biol Res Nurs 20:153-160
Mitchell, E S; Woods, N F (2015) Hot flush severity during the menopausal transition and early postmenopause: beyond hormones. Climacteric 18:536-44
Taylor-Swanson, L; Thomas, A; Ismail, R et al. (2015) Effects of traditional Chinese medicine on symptom clusters during the menopausal transition. Climacteric 18:142-56
Woods, Nancy Fugate; Cray, Lori; Mitchell, Ellen Sullivan et al. (2014) Endocrine biomarkers and symptom clusters during the menopausal transition and early postmenopause: observations from the Seattle Midlife Women's Health Study. Menopause 21:646-52
Woods, N F; Mitchell, E S; Schnall, J G et al. (2014) Effects of mind-body therapies on symptom clusters during the menopausal transition. Climacteric 17:10-22
Thomas, Annette J; Ismail, Rita; Taylor-Swanson, Lisa et al. (2014) Effects of isoflavones and amino acid therapies for hot flashes and co-occurring symptoms during the menopausal transition and early postmenopause: a systematic review. Maturitas 78:263-76
Cray, Lori A; Woods, Nancy Fugate; Herting, Jerald R et al. (2012) Symptom clusters during the late reproductive stage through the early postmenopause: observations from the Seattle Midlife Women's Health Study. Menopause 19:864-9
Cray, Lori; Woods, Nancy Fugate; Mitchell, Ellen Sullivan (2010) Symptom clusters during the late menopausal transition stage: observations from the Seattle Midlife Women's Health Study. Menopause 17:972-7
Taffe, John R; Cain, Kevin C; Mitchell, Ellen S et al. (2010) ""Persistence"" improves the 60-day amenorrhea marker of entry to late-stage menopausal transition for women aged 40 to 44 years. Menopause 17:191-3
Woods, Nancy Fugate; Mitchell, Ellen Sullivan (2010) Sleep symptoms during the menopausal transition and early postmenopause: observations from the Seattle Midlife Women's Health Study. Sleep 33:539-49

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