Chronic hemodialysis patients report that sleep alterations are major sources of stress and problems adversely affecting the quality of their lives. Subjective analyses of the sleep-wake patterns of this group suggest that daytime sleepiness is a significant problem and daytime sleep is known to profoundly affect nighttime patterns. The purpose of this study is to describe the impact that hemodialysis and the time of day at which the treatment is given have on the sleep-wake cycle and to explore related effects on functional health status and quality of life. The sample will include 40 subjects: 30 hemodialysis subjects, 10 in each of three groups based on time of treatment, and a group of 10 matched control subjects with renal insufficiency not yet receiving hemodialysis. All subjects will be screened by one to two nights of laboratory-based polysomnography to eliminate those with significant primary sleep disorders. Those individuals meeting entrance criteria will then be monitored for two 48-hour periods in their natural environment via ambulatory polysomnographic equipment. Subjects will also complete quality of life and functional health status inventories. The data obtained from this study will provide a large, objective data base regarding the sleep-wake cycles of hemodialysis patients and the effects of these patterns on quality of life and functional health status. The study will determine if and the extent to which the time of day that the treatment is given affects day and nighttime sleep. The data obtained will also provide other information necessary to develop population-specific interventions designed to manage sleep alterations in the hemodialysis population.

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Research Project (R01)
Project #
1R01NR004340-01A1
Application #
2397129
Study Section
Nursing Research Study Section (NURS)
Program Officer
Helmers, Karin F
Project Start
1997-09-01
Project End
2000-08-31
Budget Start
1997-09-01
Budget End
1998-11-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Emory University
Department
Other Health Professions
Type
Schools of Nursing
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Parker, Kathy P; Bailey, James L; Rye, David B et al. (2007) Lowering dialysate temperature improves sleep and alters nocturnal skin temperature in patients on chronic hemodialysis. J Sleep Res 16:42-50
Parker, Kathy P; Bliwise, Donald L; Bailey, James L et al. (2003) Daytime sleepiness in stable hemodialysis patients. Am J Kidney Dis 41:394-402
Parker, Kathy P (2003) Sleep disturbances in dialysis patients. Sleep Med Rev 7:131-43
Bliwise, D L; Kutner, N G; Zhang, R et al. (2001) Survival by time of day of hemodialysis in an elderly cohort. JAMA 286:2690-4
Parker, K P; Bliwise, D L; Rye, D B et al. (2000) Intradialytic subjective sleepiness and oral body temperature. Sleep 23:887-91
Parker, K P; Bliwise, D L; Rye, D B (2000) Hemodialysis disrupts basic sleep regulatory mechanisms: building hypotheses. Nurs Res 49:327-32