The purpose of this 5 years prospective, longitudinal study is to identify variables that are associated with and predict six outcomes of adult patients at 5 years to 10 years after heart transplantation (HT). The six outcomes are survival, functional ability, emotional status, work ability, satisfaction with HT, and perceived quality of life. Specific study aims are (1) to determine how variance in demographic, physical, and psychosocial factors over time is concurrently related to variance in the six outcomes over time (2) to identify demographic, physical, and psychosocial predictors of the six outcomes (3) to examine how physical and psychosocial factors that are related to the six outcomes change longitudinally (4) to examine the impact of age, gender, racial / ethnic background, and complications after HT on outcomes over time and (5) to examine the effect of using various statistical methods for handling missing data in order to improve the accuracy of prediction of outcomes. A prospective, longitudinal design will be used. Data will be collected every 6 months beginning at 5 years through 10 years after HT. Inclusion criteria are (1) >= 5 years post HT (2) age >= 21 years (3) able to read and write English, and (4) physically able to participate. Patients will complete a booklet of instruments, and chart data will be gathered. Variables to be measured include demographic variables (ex. age, gender, race, and marital status), physical variables (ex. medical history, medications, exercise testing, and complications), and psychosocial variables (ex. perceived health status, stress, coping, and social support), and the six outcome variables (within a stress, appraisal, and coping model). Statistical analyses will include longitudinal, multi-variable regression methods for repeated measures and parametric modeling of outcomes. Health-Related Implications. These data will provide information regarding (1) long-term benefits versus risks of HT, (2) patients at risk for poor outcomes, (3) and targets for interventions to improve outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Research Project (R01)
Project #
5R01NR005200-03
Application #
6490856
Study Section
Nursing Research Study Section (NURS)
Program Officer
Hare, Martha L
Project Start
2000-04-01
Project End
2004-12-31
Budget Start
2002-01-01
Budget End
2002-12-31
Support Year
3
Fiscal Year
2002
Total Cost
$301,508
Indirect Cost
Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612
Grady, Kathleen L; Andrei, Adin-Cristian; Li, Zhi et al. (2016) Gender differences in appraisal of stress and coping 5 years after heart transplantation. Heart Lung 45:41-7
Grady, Kathleen L; Wang, Edward; White-Williams, Connie et al. (2013) Factors associated with stress and coping at 5 and 10 years after heart transplantation. J Heart Lung Transplant 32:437-46
White-Williams, Connie; Grady, Kathleen L; Myers, Susan et al. (2013) The relationships among satisfaction with social support, quality of life, and survival 5 to 10 years after heart transplantation. J Cardiovasc Nurs 28:407-16
White-Williams, Connie; Grady, Kathleen L; Naftel, David C et al. (2013) The relationship of socio-demographic factors and satisfaction with social support at five and 10 yr after heart transplantation. Clin Transplant 27:267-73
Farmer, Steven A; Grady, Kathleen L; Wang, Edward et al. (2013) Demographic, psychosocial, and behavioral factors associated with survival after heart transplantation. Ann Thorac Surg 95:876-83
Shamaskin, Andrea M; Rybarczyk, Bruce D; Wang, Edward et al. (2012) Older patients (age 65+) report better quality of life, psychological adjustment, and adherence than younger patients 5 years after heart transplant: A multisite study. J Heart Lung Transplant 31:478-84
White-Williams, Connie; Wang, Edward; Rybarczyk, Bruce et al. (2011) Factors associated with work status at 5 and 10 years after heart transplantation. Clin Transplant 25:E599-605
Grady, Kathleen L; Wang, Edward; Higgins, Robert et al. (2009) Symptom frequency and distress from 5 to 10 years after heart transplantation. J Heart Lung Transplant 28:759-68
Grady, Kathleen L; Naftel, David C; Young, James B et al. (2007) Patterns and predictors of physical functional disability at 5 to 10 years after heart transplantation. J Heart Lung Transplant 26:1182-91
Grady, Kathleen L; Naftel, David C; Kobashigawa, Jon et al. (2007) Patterns and predictors of quality of life at 5 to 10 years after heart transplantation. J Heart Lung Transplant 26:535-43

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