Despite an epidemic of new HIV infections in racial and ethnic minorities and continued emphasis on minority inclusion in research, minority participation in HIV/AIDS trials has not kept pace. In rural minority communities many barriers limit access to clinical trials, at the community and individual levels. This proposal seeks to fully characterize individual and community influences on research participation in rural African Americans and Latinos and develop innovative, theory based, culturally responsive interventions.
Our specific aims are:1) define community and individual factors that influence willingness of rural racial and ethnic minorities to participate in HIV/AIDS clinical trials;2) refine a theory-based, culturally responsive outreach strategy to increase enrollment in clinical trials and evaluate the acceptability of components of this outreach from the perspective of community members, providers and individuals with HIV/AIDS;and 3) determine the feasibility of the individual enrollment session and mobile unit alone and in combination to increase willingness to participate and attendance at a follow-up referral appointment and a) explore the relationship between constructs from the conceptual model (i.e., perceived barriers, perceived benefits, perceived and social resource availability) and willingness to participate in HIV/AIDS trials. In Phase 1 focus groups with community leaders, health care/service providers, and semi-structured interviews with individuals with HIV will characterize influences on willingness to participate in research. Phase 1 participants will give feedback on a culturally responsive outreach strategy: community and provider outreach, individual enrollment sessions and a mobile trials unit. In Phase 2 we will use these data to modify the conceptual model, and use the model to develop and refine the outreach strategy. Cognitive interviews with community leaders, providers and individuals with HIV will determine the acceptability each component. In Phase 3 we will conduct a single site, 12 month assessment of the individual enrollment session and mobile unit alone and in combination using a 3 arm experimental design.

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Research Project (R01)
Project #
5R01NR010204-04
Application #
7649563
Study Section
Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
Program Officer
Hosseini, Jeanette M
Project Start
2006-09-18
Project End
2011-06-30
Budget Start
2009-07-17
Budget End
2011-06-30
Support Year
4
Fiscal Year
2009
Total Cost
$351,198
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Corbie-Smith, Giselle; Odeneye, Ebun; Banks, Bahby et al. (2013) Development of a multilevel intervention to increase HIV clinical trial participation among rural minorities. Health Educ Behav 40:274-85
Corbie-Smith, Giselle; Isler, Malika Roman; Miles, Margaret Shandor et al. (2012) Community-based HIV clinical trials: an integrated approach in underserved, rural, minority communities. Prog Community Health Partnersh 6:121-9
Isler, Malika Roman; Miles, Margaret Shandor; Banks, Bahby et al. (2012) Acceptability of a mobile health unit for rural HIV clinical trial enrollment and participation. AIDS Behav 16:1895-901
Miles, Margaret Shandor; Isler, Malika Roman; Banks, Bahby B et al. (2011) Silent endurance and profound loneliness: socioemotional suffering in African Americans living with HIV in the rural south. Qual Health Res 21:489-501
Sengupta, Sohini; Banks, Bahby; Jonas, Dan et al. (2011) HIV interventions to reduce HIV/AIDS stigma: a systematic review. AIDS Behav 15:1075-87
Sengupta, Sohini; Strauss, Ronald P; Miles, Margaret S et al. (2010) A conceptual model exploring the relationship between HIV stigma and implementing HIV clinical trials in rural communities of North Carolina. N C Med J 71:113-22