Parental illness and/or death from HIV/AIDS has a profound and lasting impact on a child's psychosocial well-being, potentially challenging the basic needs for survival and compromising the child's future. Therefore, the impact of parental HIV/AIDS on children needs to be treated from both a public health and a developmental perspective. Compelling evidence in early childhood development in the face of adversity has revealed the critical importance of resilience (e.g., successful adaptation despite risk and adversity) in laying the foundation for successful adjustment later in life. However, to date the role of a resilience-based approach among children affected by HIV is hypothesized but not evidence-based. In this application, we propose to develop a theory-guided, resilience-based, multimodal intervention by culturally adapting and integrating components from three SAMHSA model programs which show strong evidence in promoting protective factors among young children (Specific Aim #1). The adaptation process will be informed by 1) the comprehensive qualitative and quantitative data collected from our previous NIH-funded longitudinal study in rural China during the past 5 years;2) our 18 years'experience in developing and adapting effective HIV behavioral prevention programs in a broad range of cultural settings including China;and 3) our on-going research collaboration with Chinese investigators and local communities. The multimodal intervention will include three approach levels: the individual child (peer-group activities), the family (caregiver parenting skill training), and the local community (community advocacy). The short, medium, and long-term efficacy of the Child-Caregiver-Advocacy-Resilience [ChildCARe] intervention to improve health and psychosocial well-being of children will be evaluated over 36 months through a cluster randomized controlled trial (Specific Aim #2). Eight hundred HIV/AIDS-affected children (8 to 11 years of age) and their primary caregivers will be recruited from 80 villages in central China where we have built a strong research infrastructure and community collaboration during our previous study. The primary outcome measures for the children will include physical health, mental health, growth and development, school performance, and a biological indicator of neurobiological stress response (salivary cortisol). The outcome measures at caregiver level will include parenting style, parental engagement, and mental health well-being. The changes at the community level will be measured using children's and caregivers'perceptions of social support and HIV-related public stigma. We will also examine the potential mechanism through which the ChildCARe intervention is exerting its impact by identifying improvement in protective factors and other individual and contextual factors that potentially mediate or moderate the intervention effect (Specific Aim #3). This proposed project will examine whether the multilevel protective factors we identified in our initial project are amenable to intervention and whether their hypothesized changes explain improvement in children outcomes. This application provides an alternative to a """"""""deficit"""""""" paradigm of intervention and shifts our conceptualization from pathology to resilience. The combination of self-report data and data from laboratory tests of salivary cortical will provide an opportunity to examine whether the prevention impact of a resilience-based intervention can extend to domains beyond behaviors.

Public Health Relevance

In response to the overarching goal of FOA#RFA-HD-10-017, we propose to develop, implement, and evaluate a theory-driven, resilience-based multimodal (child-caregiver-community) intervention [ChildCARe] to promote psychosocial well-being among children affected by HIV/AIDS. The scientifically rigorous evaluation effort includes a randomized controlled trial and multiple psychosocial and biological outcome measures, and is culturally sensitive to the local environment. We hypothesize that our proposed ChildCARe intervention will foster multilevel protective factors in children and their living environment that can ameliorate the consequences of parental HIV/AIDS, thereby improve the children's well-being, security, and developmental progress toward healthy adulthood. The ChildCARe intervention to be developed and the evaluation data to be collected will inform the practices and policies aimed at improving health and well-being and future outcomes among children affected by HIV/AIDS in China and around the globe.

National Institute of Health (NIH)
National Institute of Nursing Research (NINR)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-M (17))
Program Officer
Hardy, Lynda R
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Wayne State University
Schools of Medicine
United States
Zip Code
Li, Xiaoming; Harrison, Sayward E; Fairchild, Amanda J et al. (2017) A randomized controlled trial of a resilience-based intervention on psychosocial well-being of children affected by HIV/AIDS: Effects at 6- and 12-month follow-up. Soc Sci Med 190:256-264
Zilioli, Samuele; Slatcher, Richard B; Chi, Peilian et al. (2017) The impact of daily and trait loneliness on diurnal cortisol and sleep among children affected by parental HIV/AIDS. Psychoneuroendocrinology 75:64-71
Chen, Lihua; Chi, Peilian; Li, Xiaoming et al. (2017) The effects of trait and state affect on diurnal cortisol slope among children affected by parental HIV/AIDS in rural China. AIDS Care 29:1034-1040
Zilioli, Samuele; Slatcher, Richard B; Chi, Peilian et al. (2016) Childhood Adversity, Self-Esteem, and Diurnal Cortisol Profiles Across the Life Span. Psychol Sci 27:1249-65
Wei, Wei; Li, Xiaoming; Tu, Xiaoming et al. (2016) Perceived social support, hopefulness, and emotional regulations as mediators of the relationship between enacted stigma and post-traumatic growth among children affected by parental HIV/AIDS in rural China. AIDS Care 28 Suppl 1:99-105
Wei, Wei; Li, Xiaoming; Harrison, Sayward et al. (2016) The relationships between HIV stigma, emotional status, and emotional regulation among HIV-affected children in rural China. AIDS Care 28 Suppl 2:161-7
Chi, Peilian; Slatcher, Richard B; Li, Xiaoming et al. (2015) Perceived Stigmatization, Resilience, and Diurnal Cortisol Rhythm Among Children of Parents Living With HIV. Psychol Sci 26:843-52
Zhao, Junfeng; Li, Xiaoming; Qiao, Shan et al. (2015) Parental HIV disclosure: from perspectives of children affected by HIV in Henan, China. AIDS Care 27:416-23
Li, Xiaoming; Chi, Peilian; Sherr, Lorraine et al. (2015) Psychological Resilience among Children Affected by Parental HIV/AIDS: A Conceptual Framework. Health Psychol Behav Med 3:217-235
Ferro, Mark A; Boyle, Michael H; Avison, William R (2015) Association between trajectories of maternal depression and subsequent psychological functioning in youth with and without chronic physical illness. Health Psychol 34:820-828

Showing the most recent 10 out of 22 publications