Can the Sunshine Vitamin Improve Mood and Self-Management in Women with Diabetes? Diabetes affects 1 in 10 persons in the United States and is projected to increase to 1 in 4 persons by 2050. Women with type 2 diabetes have worse outcomes than men with type 2 diabetes. This may be due to depression which affects over 25% of women with diabetes. Depression interferes with self-care behaviors and significantly impacts glycemic control. Antidepressants are effective for the treatment of depression but can disrupt glycemic control and cause weight gain, making diabetes self-management challenging. Research has shown that vitamin D supplementation can improve depressive symptoms in healthy, obese individuals suggesting its use for amelioration of these symptoms in other groups. We recently completed a six month proof of concept study using a one group, pre-post test design to examine the effects of weekly vitamin D supplementation (50,000 IUs weekly) in women with type 2 diabetes who had significant depressive symptoms (a score >16 on the Center for Epidemiologic Studies Depression Tool (CES-D) (NIH 5P60DK020595, pilot project). We found a significant decrease in depression symptoms, improvements in diabetes self- management, and a decrease in systolic blood pressure. Several small studies have shown that vitamin D supplementation may lower blood pressure by direct and indirect vascular effects. We now propose a randomized trial to determine the efficacy of vitamin D3 supplementation on depressive symptoms, self- management, and blood pressure in women with type 2 diabetes who have significant depressive symptoms (n=150). Using a stratified block randomization (strata based on depression symptom severity) women will be assigned to either weekly vitamin D3 supplementation (50,000 IUs) or a matching weekly placebo for a period of six months. Since guidelines recommend assessing vitamin D levels at three months upon initiating this dose, study measurements will be collected at baseline, three, and six months. The following outcomes will be measured: depressive symptoms, diabetes self-management (self-efficacy, diabetes distress, diabetes self- care behaviors), and systolic blood pressure. We hypothesize that women receiving vitamin D3 supplementation will report fewer depressive symptoms, increased diabetes self- management mediated by depression improvement, and have a lower systolic BP compared to those taking placebo. We will also explore a possible mechanistic effect of vitamin D supplementation on depression. Evidence indicates that in depression, pro-inflammatory biomarkers, notably cytokines and C-reactive protein (CRP), are elevated. Some of these inflammatory biomarkers alter the metabolic pathway of tryptophan by shunting it away from serotonin synthesis via stimulation of the enzyme indoleamine 2, 3-dioxygenase (IDO). Several studies (not depression studies) have reported that Vitamin D can decrease levels of inflammatory biomarkers. Thus we will explore whether vitamin D supplementation decreases inflammatory biomarkers (CRP, interleukin-6, and tumor necrosis factor- ?) providing evidence for a plausible mechanism of antidepressant activity. Vitamin D supplementation has minimal side effects and is low in cost. Thus, the potential for using this therapy is highly significant fr women with type 2 diabetes and other chronic populations who suffer from symptoms of depression which significantly impacts the self-management of their health.

Public Health Relevance

Can the Sunshine Vitamin Improve Mood and Self-Management in Women with Diabetes? Public Information: Vitamin D deficiency is a worldwide problem with research to suggest it may be beneficial to mental well being. Evidence indicates that insufficient levels of vitamin D are associated with depressive symptoms. Women with diabetes are burdened with these symptoms which can significantly affect their diabetes self- management. Women with diabetes also have insufficient levels of vitamin D. This study will determine whether providing vitamin D supplementation can improve mood and subsequently enhance diabetes self-management. If effective, this could be a low cost treatment for women with type 2 diabetes who are at greatest risk for depression and poor glycemic control.

National Institute of Health (NIH)
National Institute of Nursing Research (NINR)
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Special Emphasis Panel (ZRG1-NRCS-B (08))
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Aziz, Noreen M
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Loyola University Chicago
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United States
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Ridosh, Monique M; Roux, Gayle; Meehan, Meghan et al. (2017) Barriers to Self-Management in Depressed Women With Type 2 Diabetes. Can J Nurs Res 49:160-169
Penckofer, Sue; Byrn, Mary; Adams, William et al. (2017) Vitamin D Supplementation Improves Mood in Women with Type 2 Diabetes. J Diabetes Res 2017:8232863
Penckofer, Sue; Doyle, Todd; Byrn, Mary et al. (2014) State of the science: depression and type 2 diabetes. West J Nurs Res 36:1158-82
Meehan, Meghan; Penckofer, Sue (2014) The Role of Vitamin D in the Aging Adult. J Aging Gerontol 2:60-71