In the Department of Otolaryngology at the Johns Hopkins Hospital, clinical investigations are carried out on patients with cochlear and vestibular dysfunctions and a variety of pathological conditions involving the different structures of the temporal bone. These investigations include an oto-neurological examination, cochlear and vestibular function studies, roentgenological investigations, and when indicated, additional diagnostic studies. The roentgenological, medical, neurological and neurosurgical examinations are performed by the respective services. At autopsy the temporal bones are removed. These temporal bones are subsequently prepared for microscopic examination in the Temporal Bone Pathology Laboratory located in the Traylor Research Building of the Johns Hopkins University School of Medicine. The objectives of this research are to correlate clinical and histopathological observations and thereby to increase knowledge about the poorly understood mechanisms of certain disease processes involving the cochlea and vestibular labyrinth and other structures of the human temporal bone. The selective collection of temporal bones from patients with diseases involving the ear, who have been carefully studied, represents a valuable approach which obviously will continue to add significant information to a better understanding of the nature and the sequence of events in the development of impairment of hearing and dysfunction of equilibrium. Once the pathogenesis is better understood, prevention of a disease process becomes a possibility.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS002182-25
Application #
3393231
Study Section
Hearing Research Study Section (HAR)
Project Start
1974-12-01
Project End
1986-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
25
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Nager, G T; Proctor, B (1991) Anatomic variations and anomalies involving the facial canal. Otolaryngol Clin North Am 24:531-53
Nager, G T (1988) Osteogenesis imperfecta of the temporal bone and its relation to otosclerosis. Ann Otol Rhinol Laryngol 97:585-93
Nager, G T (1987) Cephaloceles. Laryngoscope 97:77-84
Nager, G T; Hamersma, H (1986) Sclerosteosis involving the temporal bone: histopathologic aspects. Am J Otolaryngol 7:1-16
Nager, G T (1986) Solitary (unicameral) cysts involving the temporal bone. Laryngoscope 96:666-74