Abstract

Mechanisms of sensory transduction and its modification by motor control will be studied in mammalian muscle spindles, both in situ and in isolated preparations. The membrane properties and contractile activation of intrafusal muscle fibers as well as their passive mechanical properties will be investigated using intracellular recording and stimulation and microscopic measurement of sarcomere length changes. The roles of the 2 types of nuclear bag fiber will be tested by activation of these fibers individually while observing the effect on the primary ending response to stretch. Possible stretch excitation in bag fibers will be studied. The conductance change in the sensory terminals in response to stretch will also be investigated as will the characteristics of impulse initiation in the primary ending.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS007907-19
Application #
3393686
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1979-01-01
Project End
1988-12-31
Budget Start
1986-01-01
Budget End
1986-12-31
Support Year
19
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Petit, J; Filippi, G M; Emonet-Denand, F et al. (1990) Changes in muscle stiffness produced by motor units of different types in peroneus longus muscle of cat. J Neurophysiol 63:190-7
Petit, J; Filippi, G M; Gioux, M et al. (1990) Effects of tetanic contraction of motor units of similar type on the initial stiffness to ramp stretch of the cat peroneus longus muscle. J Neurophysiol 64:1724-32
Hunt, C C (1990) Mammalian muscle spindle: peripheral mechanisms. Physiol Rev 70:643-63
Duncan, M J; Takahashi, J S; Dubocovich, M L (1989) Characteristics and autoradiographic localization of 2-[125I]iodomelatonin binding sites in Djungarian hamster brain. Endocrinology 125:1011-8
Duncan, M J; Takahashi, J S; Dubocovich, M L (1988) 2-[125I]iodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution. Endocrinology 122:1825-33
Emonet-Denand, F; Hunt, C C; Petit, J et al. (1988) Proportion of fatigue-resistant motor units in hindlimb muscles of cat and their relation to axonal conduction velocity. J Physiol 400:135-58
Azerad, J; Hunt, C C; Laporte, Y et al. (1986) Afferent fibres in cat ventral roots: electrophysiological and histological evidence. J Physiol 379:229-43
Adal, M N (1986) The transverse tubular system of cat intrafusal muscle fibres. Cell Tissue Res 244:197-202
Emonet-Denand, F; Hunt, C C; Laporte, Y (1985) Fusimotor after-effects on responses of primary endings to test dynamic stimuli in cat muscle spindles. J Physiol 360:187-200
Emonet-Denand, F; Hunt, C C; Laporte, Y (1985) Effects of stretch on dynamic fusimotor after-effects in cat muscle spindles. J Physiol 360:201-13