Abstract

The proposed research will endeavor to determine: (1) afferent projections of hindlimb cutaneous nerves to cat lumbosacral dorsal horn (using both anatomical and physiological methods); (2) physiological connectivities among dorsal horn cells, using cross-correlation techniques; (3) properties of substantia gelatinosa neurons, using waveform recognition and source-sink mapping; and (4) responses of dorsal horn cells to a variety of quantitatively controlled inputs, such as single action potentials, action potential pairs, and larger inputs evoked by stimulating larger areas of skin.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS012061-10S1
Application #
3394696
Study Section
(NY)
Project Start
1979-08-01
Project End
1988-02-29
Budget Start
1986-07-01
Budget End
1988-02-29
Support Year
10
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
West Virginia University
Department
Type
School of Medicine & Dentistry
DUNS #
191510239
City
Morgantown
State
WV
Country
United States
Zip Code
26506

  Publications

Koerber, H R; Brown, P B (1995) Quantitative analysis of dorsal horn cell receptive fields following limited deafferentation. J Neurophysiol 74:2065-76
Gladfelter, W E; Millecchia, R J; Pubols, L M et al. (1993) Crossed receptive field components and crossed dendrites in cat sacrocaudal dorsal horn. J Comp Neurol 336:96-105
Brown, P B; Gladfelter, W E; Culberson, J C et al. (1991) Somatotopic organization of single primary afferent axon projections to cat spinal cord dorsal horn. J Neurosci 11:298-309
Millecchia, R J; Pubols, L M; Sonty, R V et al. (1991) Influence of map scale on primary afferent terminal field geometry in cat dorsal horn. J Neurophysiol 66:696-704
Culberson, J L; Brushart, T M (1989) Somatotopy of digital nerve projections to the cuneate nucleus in the monkey. Somatosens Mot Res 6:319-30
Ritz, L A; Brown, P B; Bailey, S M (1989) Crossed and uncrossed projections to cat sacrocaudal spinal cord: I. Axons from cutaneous receptors. J Comp Neurol 289:284-93
Brown, P B; Brushart, T M; Ritz, L A (1989) Somatotopy of digital nerve projections to the dorsal horn in the monkey. Somatosens Mot Res 6:309-17
Brown, P B; Ritz, L A (1986) Dorsal horn potentials and current source densities evoked by single action potentials in single slowly adapting type I axons. J Neurophysiol 55:1104-13
Ritz, L A; Culberson, J L; Brown, P B (1985) Somatotopic organization in cat spinal cord segments with fused dorsal horns: caudal and thoracic levels. J Neurophysiol 54:1167-77