Abstract

Single neurons in the parahippocampal region (subiculum, presubiculum, postsubiculum, parasubiculum, entorhinal cortex and perirhinal cortex) will be recorded in freely moving rats. A TV-computer based system will be developed to measure firing of a neuron as a function of head direction, place and head direction, place, and speed, turning of the head from side to side, and head elevation and pitch. The stimuli which control these spatial sensory-behavioral correlates of firing will be studied. Firing in different environments will be studied looking for constancies across environments, and ways in which these constancies can be disrupted. Electrophysiological studies of the projections of the neurons studied will be made. The slow wave theta rhythm and the relation of cell firing to the theta rhythm will be studied.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS014497-09
Application #
3395571
Study Section
Biopsychology Study Section (BPO)
Project Start
1978-04-01
Project End
1990-11-30
Budget Start
1986-09-01
Budget End
1987-11-30
Support Year
9
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Suny Downstate Medical Center
Department
Type
Schools of Medicine
DUNS #
068552207
City
Brooklyn
State
NY
Country
United States
Zip Code
11203

  Publications

Muller, R U; Stead, M; Pach, J (1996) The hippocampus as a cognitive graph. J Gen Physiol 107:663-94
Muller, R U; Ranck Jr, J B; Taube, J S (1996) Head direction cells: properties and functional significance. Curr Opin Neurobiol 6:196-206
Muller, R U; Bostock, E; Taube, J S et al. (1994) On the directional firing properties of hippocampal place cells. J Neurosci 14:7235-51
Quirk, G J; Muller, R U; Kubie, J L et al. (1992) The positional firing properties of medial entorhinal neurons: description and comparison with hippocampal place cells. J Neurosci 12:1945-63
Quirk, G J; Muller, R U; Kubie, J L (1990) The firing of hippocampal place cells in the dark depends on the rat's recent experience. J Neurosci 10:2008-17
Taube, J S; Muller, R U; Ranck Jr, J B (1990) Head-direction cells recorded from the postsubiculum in freely moving rats. I. Description and quantitative analysis. J Neurosci 10:420-35
Taube, J S; Muller, R U; Ranck Jr, J B (1990) Head-direction cells recorded from the postsubiculum in freely moving rats. II. Effects of environmental manipulations. J Neurosci 10:436-47
Muller, R U; Kubie, J L; Ranck Jr, J B (1987) Spatial firing patterns of hippocampal complex-spike cells in a fixed environment. J Neurosci 7:1935-50
Fox, S E; Wolfson, S; Ranck Jr, J B (1986) Hippocampal theta rhythm and the firing of neurons in walking and urethane anesthetized rats. Exp Brain Res 62:495-508