Antibodies will be raised that are specific for a potent activator of the acetylcholine receptor (AChR), trans-3,3'-BisQ. The specificity of these antibodies will be determined with respect to other compounds that bind to AChR in order to determine whether homology of binding exists in AChR and the specific antibody. If so, the antisera will be used to screen for other cholinergic compounds. An attempt will also be made to prepare homogeneous globulin (i.e. antibody) protein specific for trans-3, 3'-BisQ to further characterize its binding properties. Finally, anti-idiotypic antibodies will be prepared and its specificity for AChR determined. All of the objectives are related to gaining an understanding of the function of AChR in health and disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS015581-11
Application #
3396343
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1979-09-24
Project End
1992-03-31
Budget Start
1990-09-01
Budget End
1992-03-31
Support Year
11
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
Schools of Medicine
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027
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