Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS016708-14
Application #
2263079
Study Section
Special Emphasis Panel (ZRG2-PHY (02))
Project Start
1981-01-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Hebrew University of Jerusalem
Department
Type
DUNS #
600044978
City
Jerusalem
State
Country
Israel
Zip Code
91904
Silverstein, Nechama; Sliman, Alaa; Stockner, Thomas et al. (2018) Both reentrant loops of the sodium-coupled glutamate transporters contain molecular determinants of cation selectivity. J Biol Chem 293:14200-14209
Yaffe, Dana; Forrest, Lucy R; Schuldiner, Shimon (2018) The ins and outs of vesicular monoamine transporters. J Gen Physiol 150:671-682
Yaffe, Dana; Vergara-Jaque, Ariela; Forrest, Lucy R et al. (2016) Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis. Proc Natl Acad Sci U S A 113:E7390-E7398
Silverstein, Nechama; Ewers, David; Forrest, Lucy R et al. (2015) Molecular Determinants of Substrate Specificity in Sodium-coupled Glutamate Transporters. J Biol Chem 290:28988-96
Yaffe, Dana; Vergara-Jaque, Ariela; Shuster, Yonatan et al. (2014) Functionally important carboxyls in a bacterial homologue of the vesicular monoamine transporter (VMAT). J Biol Chem 289:34229-40
Schuldiner, Shimon (2014) Competition as a way of life for H(+)-coupled antiporters. J Mol Biol 426:2539-46
Shabaneh, Mustafa; Rosental, Noa; Kanner, Baruch I (2014) Disulfide cross-linking of transport and trimerization domains of a neuronal glutamate transporter restricts the role of the substrate to the gating of the anion conductance. J Biol Chem 289:11175-82
Yaffe, Dana; Radestock, Sebastian; Shuster, Yonatan et al. (2013) Identification of molecular hinge points mediating alternating access in the vesicular monoamine transporter VMAT2. Proc Natl Acad Sci U S A 110:E1332-41
Ugolev, Yelena; Segal, Tali; Yaffe, Dana et al. (2013) Identification of conformationally sensitive residues essential for inhibition of vesicular monoamine transport by the noncompetitive inhibitor tetrabenazine. J Biol Chem 288:32160-71
Silverstein, Nechama; Crisman, Thomas J; Forrest, Lucy R et al. (2013) Cysteine scanning mutagenesis of transmembrane helix 3 of a brain glutamate transporter reveals two conformationally sensitive positions. J Biol Chem 288:964-73

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