The objective of this research program is to understand the structural and functional significance of the cerebral cortex. Our previous research has focused upon the long cortical connections that link sensory, association and limbic cortical areas. These studies have revealed underlying principles of the organization of cortical connections. Our recent investigations have focused on the intrinsic connectivity and cytoarchitecture of the auditory cortices and have revealed that the intrinsic connections of the auditory areas are organized according to a set of principles that appears linked to the cytoarchitectonic subdivision of these areas. This organizational pattern is also reflected in the thalamocortical connections of each subdivision. Additional studies have suggested that similar organizational principles may govern the local connectivity of the inferotemporal and posterior parahippocampal areas of the ventral temporal lobe, regions that may constitute parallel streams for the outflow of visual information from the occipital lobe. The visual input to the inferotemporal cortex appears to originate primarily in areas where the central part of the visual field is represented while input to the posterior parahippocampal gyrus originates in areas where the peripheral part of the visual field is represented. This suggests that these two areas may constitute two distinct visual pathways through the temporal lobe. Our proposed studies are designed to examine this hypothesis by investigating the connections of the occipital cortices leading to both the inferotemporal and posterior parahippocampal areas. We also propose to investigate the differential thalamocortical and corticothalamic connectivity of each stage along these parallel pathways. Additionally, in the posterior parahippocampal gyrus we will determine the relationship of these visual and thalamic afferents to afferents from the parietal, superior temporal, frontal and limbic cortices. Finally, we will investigate the efferent outflow from these various architectonic subdivisions of the inferotemporal and posterior parahippocampal areas into the limbic system of the medial temporal lobe: the entorhinal areas, the hippocampal formation and the amygdala. These studies will be conducted in the rhesus monkey using complementary anterograde and retrograde tracing techniques.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS016841-09
Application #
3397191
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1981-02-01
Project End
1991-01-31
Budget Start
1989-02-01
Budget End
1990-01-31
Support Year
9
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Boston University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Yeterian, Edward H; Pandya, Deepak N; Tomaiuolo, Francesco et al. (2012) The cortical connectivity of the prefrontal cortex in the monkey brain. Cortex 48:58-81
Blatt, Gene J; Pandya, Deepak N; Rosene, Douglas L (2003) Parcellation of cortical afferents to three distinct sectors in the parahippocampal gyrus of the rhesus monkey: an anatomical and neurophysiological study. J Comp Neurol 466:161-79
Cipolloni, P B; Pandya, D N (1999) Cortical connections of the frontoparietal opercular areas in the rhesus monkey. J Comp Neurol 403:431-58
Blatt, G J; Rosene, D L (1998) Organization of direct hippocampal efferent projections to the cerebral cortex of the rhesus monkey: projections from CA1, prosubiculum, and subiculum to the temporal lobe. J Comp Neurol 392:92-114
Pandya, D N; Rosene, D L; Doolittle, A M (1994) Corticothalamic connections of auditory-related areas of the temporal lobe in the rhesus monkey. J Comp Neurol 345:447-71
Chesselet, M F; Mercugliano, M; Soghomonian, J J et al. (1993) Regulation of glutamic acid decarboxylase gene expression in efferent neurons of the basal ganglia. Prog Brain Res 99:143-54
Pandya, D N; Rosene, D L (1993) Laminar termination patterns of thalamic, callosal, and association afferents in the primary auditory area of the rhesus monkey. Exp Neurol 119:220-34
Rhodes, K J; Meiners, K A; Rosene, D L (1993) A novel hinge system and incubation chamber for emulsion-coated coverslip autoradiography. J Histochem Cytochem 41:1419-27
Soghomonian, J J; Gonzales, C; Chesselet, M F (1992) Messenger RNAs encoding glutamate-decarboxylases are differentially affected by nigrostriatal lesions in subpopulations of striatal neurons. Brain Res 576:68-79
Seltzer, B; Pandya, D N (1991) Post-rolandic cortical projections of the superior temporal sulcus in the rhesus monkey. J Comp Neurol 312:625-40

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