Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS017742-13
Application #
2263269
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1982-07-01
Project End
1996-11-30
Budget Start
1994-12-01
Budget End
1996-11-30
Support Year
13
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Microbiology/Immun/Virology
Type
Schools of Earth Sciences/Natur
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

DasGupta, Bibhuti R (2006) Botulinum neurotoxins: perspective on their existence and as polyproteins harboring viral proteases. J Gen Appl Microbiol 52:1-8
Dasgupta, Bibhuti R; Antharavally, Babu S; Tepp, William et al. (2005) Botulinum neurotoxin types A, B, and E: fragmentations by autoproteolysis and other mechanisms including by O-phenanthroline-dithiothreitol, and association of the dinucleotides NAD(+)/NADH with the heavy chain of the three neurotoxins. Protein J 24:337-68
Prabakaran, S; Tepp, W; DasGupta, B R (2001) Botulinum neurotoxin types B and E: purification, limited proteolysis by endoproteinase Glu-C and pepsin, and comparison of their identified cleaved sites relative to the three-dimensional structure of type A neurotoxin. Toxicon 39:1515-31
Flicker, P F; Robinson, J P; DasGupta, B R (1999) Is formation of visible channels in a phospholipid bilayer by botulinum neurotoxin type B sensitive to its disulfide? J Struct Biol 128:297-304
Antharavally, B; Tepp, W; DasGupta, B R (1998) Status of Cys residues in the covalent structure of botulinum neurotoxin types A, B, and E. J Protein Chem 17:187-96
Antharavally, B S; DasGupta, B R (1998) Covalent structure of botulinum neurotoxin type B;location of sulfhydryl groups and disulfide bridge and identification of C-termini of light and heavy chains. J Protein Chem 17:417-28
Lawrence, G W; Foran, P; Mohammed, N et al. (1997) Importance of two adjacent C-terminal sequences of SNAP-25 in exocytosis from intact and permeabilized chromaffin cells revealed by inhibition with botulinum neurotoxins A and E. Biochemistry 36:3061-7
Beecher, D J; DasGupta, B R (1997) Botulinum neurotoxin type A: limited proteolysis by endoproteinase Glu-C and alpha-chymotrypsin enhanced following reduction; identification of the cleaved sites and fragments. J Protein Chem 16:701-12
Antharavally, B S; DasGupta, B R (1997) Covalent structure of botulinum neurotoxin type E: location of sulfhydryl groups, and disulfide bridges and identification of C-termini of light and heavy chains. J Protein Chem 16:787-99
Emanuel, P; O'Brien, T; Burans, J et al. (1996) Directing antigen specificity towards botulinum neurotoxin with combinatorial phage display libraries. J Immunol Methods 193:189-97

Showing the most recent 10 out of 74 publications