Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS018660-12
Application #
2263461
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1986-08-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cornell University
Department
Pharmacology
Type
Schools of Veterinary Medicine
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Vazquez, R W; Oswald, R E (1999) Identification of a new amino acid residue capable of modulating agonist efficacy at the homomeric nicotinic acetylcholine receptor, alpha7. Mol Pharmacol 55:1-7
Stafford, G A; Oswald, R E; Figl, A et al. (1998) Two domains of the beta subunit of neuronal nicotinic acetylcholine receptors contribute to the affinity of substance P. J Pharmacol Exp Ther 286:619-26
Carter, A A; Oswald, R E (1995) Linear prediction and single-channel recording. J Neurosci Methods 60:69-78
Stafford, G A; Oswald, R E; Weiland, G A (1994) The beta subunit of neuronal nicotinic acetylcholine receptors is a determinant of the affinity for substance P inhibition. Mol Pharmacol 45:758-62
McGroddy, K A; Brady, J W; Oswald, R E (1994) Computer simulations of cyclic and acyclic cholinergic agonists: conformational search and molecular dynamics simulations. Biophys J 66:314-24
McGroddy, K A; Oswald, R E (1993) Solution structure and dynamics of cyclic and acyclic cholinergic agonists. Biophys J 64:314-24
McGroddy, K A; Carter, A A; Tubbert, M M et al. (1993) Analysis of cyclic and acyclic nicotinic cholinergic agonists using radioligand binding, single channel recording, and nuclear magnetic resonance spectroscopy. Biophys J 64:325-38
Carter, A A; Oswald, R E (1993) Channel blocking properties of a series of nicotinic cholinergic agonists. Biophys J 65:840-51
Coleman, B A; Oswald, R E (1993) Identification of the benzomorphan opiate binding site on the catalytic subunit of acetylcholinesterase. Mol Pharmacol 43:217-25
Sutcliffe, M J; Dobson, C M; Oswald, R E (1992) Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: calculation of tertiary structure using systematic homologous model building, dynamical simulated annealing, and restrained molecular dynamics. Biochemistry 31:2962-70

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