This project will continue studies on the effects of vestibulo-toxic aminoglycoside antibiotics on the dynamics of human vestibulo-ocular reflex (VOR) and vestibulo-spinal (VS) systems. The adaptive properties of the VOR and VS systems will be studied in patients who suffer vestibular ototoxicity. Conventional techniques, including caloric, saccadic eye movement, and optokinetic (oculamotor screening) tests will be performed in addition to rotational VOR and moving platform/visual surrounds VS tests. These VOR and VS test methods will be employed in various combinations in order to accomplish the project's specific aims. Results of this project will significantly advance the health care of patients who must receive life-saving ototoxic antibiotics by: 1) detecting ototoxicity at onset; 2) determining risk for ototoxicity at onset of treatment; 3) determining relative incidence of vestibular ototoxicity for the more commonly used aminoglycosides; and 4) characterizing adaptive motor reflex mechanisms in patients with vestibular ototoxicity. The development of rehabilitation strategies for subjects who became severely ototoxic will be enhanced by an improved understanding of adaptive motor reflex mechanisms.
| Black, F Owen; Pesznecker, Susan C; Homer, Louis et al. (2004) Benign paroxysmal positional nystagmus in hospitalized subjects receiving ototoxic medications. Otol Neurotol 25:353-8 |
| Black, F O; Gianna-Poulin, C; Pesznecker, S C (2001) Recovery from vestibular ototoxicity. Otol Neurotol 22:662-71 |
| Black, F O; Wade, S W; Nashner, L M (1996) What is the minimal vestibular function required for compensation? Am J Otol 17:401-9 |
| Nashner, L M; Shupert, C L; Horak, F B et al. (1989) Organization of posture controls: an analysis of sensory and mechanical constraints. Prog Brain Res 80:411-8;discussion 395-7 |
| Black, F O; Lilly, D J; Peterka, R J et al. (1987) Vestibulo-ocular and vestibulospinal function before and after cochlear implant surgery. Ann Otol Rhinol Laryngol Suppl 96:106-8 |
| Black, F O; Peterka, R J; Elardo, S M (1987) Vestibular reflex changes following aminoglycoside induced ototoxicity. Laryngoscope 97:582-6 |
| Black, F O; Lilly, D J; Fowler, L P et al. (1987) Surgical evaluation of candidates for cochlear implants. Ann Otol Rhinol Laryngol Suppl 96:96-9 |
