This study seeks to continue investigations on genetic mechanisms in the control of central dopaminergic (DA) systems. First, genetic selection experiments will be carried out with mice for high and low number of DA neurons in substantia nigra (Ag cell group). In the selection experiments we wish to determine if: a., there is a common genetic control on the number of DA neurons shared by all DA systems in the brain, b., cellular characteristics of DA systems (such as number of cell bodies and axonal arborization) are affected by identical or separate genetic mechanisms, c., changes in number of DA neurons are correlated with natural and drug-induced behaviors mediated by DA neurons. The established lines can be used as models for disorders where comparable deviations in DA systems are involved (e.g. Parkinson's disease). Second, we wish to study if there are major gene effects on brain DA systems. Third, the selected lines will be studied to determine if genetic differences in the tuberohypophyseal DA systems are correlated with size and neuronal number in pars intermedia of hypophysis, Beta-Endorphin, and Alpha-MSH secretion, and behavioral processes effected by these hormones.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS019788-05
Application #
3399874
Study Section
Neurology C Study Section (NEUC)
Project Start
1983-08-01
Project End
1989-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
5
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Nathan Kline Institute for Psychiatric Research
Department
Type
DUNS #
167204762
City
Orangeburg
State
NY
Country
United States
Zip Code
10962
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Zaborszky, L; Vadasz, C (2001) The midbrain dopaminergic system: anatomy and genetic variation in dopamine neuron number of inbred mouse strains. Behav Genet 31:47-59
Vadasz, C; Sziraki, I; Sasvari, M et al. (1998) Analysis of the mesotelencephalic dopamine system by quantitative-trait locus introgression. Neurochem Res 23:1337-54
Vadasz, C; Sziraki, I; Murthy, L R et al. (1994) Transfer of brain dopamine system-specific quantitative trait loci onto a C57BL/6ByJ background. Mamm Genome 5:735-7
Vadasz, C; Kobor, G; Lajtha, A (1992) Motor activity and the mesotelencephalic dopamine function. I. High-resolution temporal and genetic analysis of open-field behavior. Behav Brain Res 48:29-39
Vadasz, C; Kobor, G; Lajtha, A (1992) Motor activity and the mesotelencephalic dopamine function. II. Multivariate analysis of genetically segregating generations. Behav Brain Res 48:41-7
Vadasz, C; Kobor, G; Kabai, P et al. (1988) Perinatal anti-androgen treatment and genotype affect the mesotelencephalic dopamine system and behavior in mice. Horm Behav 22:528-39
Vadasz, C; Sziraki, I; Murthy, L R et al. (1987) Genetic determination of mesencephalic tyrosine hydroxylase activity in the mouse. J Neurogenet 4:241-52
Sziraki, I; Murthy, L R; Lajtha, A et al. (1987) Genetic determination of hypothalamic tyrosine hydroxylase activity in mice. Brain Res Bull 18:13-8
Vadasz, C; Sziraki, I; Murthy, L R et al. (1986) Genetic determination of striatal tyrosine hydroxylase activity in mice. Neurochem Res 11:1139-49