Our overall goal is to understand the operation of the cochlea, in particular the mechanisms through which mechanical signals that enter the cochlea lead to the discharge of nerve fibers that leave the cochlea and enter the brain. We measure physiological variables at key stages in the cochleae of anesthetized alligator lizards and relate these through theoretical models of the underlying mechanisms. Much information has already been obtained on the alligator lizard car: the anatomy is well-described; measurements have been made of the mechanics of the middle and inner ear, the motion of the stereocilia, the receptor potentials of hair cells, the responses of supporting cells, the electromechanical environment of the receptor organ, and the spike discharges of cochlear nerve fibers. In this application, we propose a combined experimental and theoretical investigation of this ear with the aim of formulating a comprehensive model relating the sound pressure at the tympanic membrane to the discharges of cochlear nerve fibers in terms of the underlying structures and mechanisms. Many of these structures and mechanisms are common to all vertebrates. Hence, our findings should have general significance for understanding cochlear processes. Because our present understanding of cochlear processes is so incomplete, diagnosis and treatment of hearing impairments of cochlear origin are often purely empirical. More useful management of cochlear dysfunction will evolve when we have a clearer understanding of normal cochlear mechanisms.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS020322-04
Application #
3400623
Study Section
Hearing Research Study Section (HAR)
Project Start
1984-06-01
Project End
1991-05-31
Budget Start
1987-06-01
Budget End
1988-05-31
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139