Narcolepsy is a neurological disorder of unknown origin that afflicts about 1 in 1000 Americans. Clinically, narcolepsy first appears in adolescence or young adulthood as irresistible urges to sleep. Auxillary symptoms are cataplexy, hypnagogic hallucinations and sleep paralysis. The disease has been linked to problems ranging from """"""""under achievement in school"""""""" to """"""""unhappy marriage"""""""" to """"""""death in traffic accidents."""""""" The research is designed to evaluate the most frequently used treatments for this disorder. We will complete a double-blind, multiple-drug, multiple-dose level study on drug therapy in narcoleptic patients. A repeated-measures design has been employed and a normal control group is being studied to assess the effect of repeated measurement and to gather normative data. We plan to complete studies comparing the relative effectiveness of four drugs in common use for control of excessive somnolence in narcolepsy: pemoline, methylphenidate protriptyline, and dextroamphetamine.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS020459-05S1
Application #
3400788
Study Section
(SSS)
Project Start
1983-06-01
Project End
1990-06-30
Budget Start
1989-09-29
Budget End
1990-06-30
Support Year
5
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92037
Doghramji, K; Mitler, M M; Sangal, R B et al. (1997) A normative study of the maintenance of wakefulness test (MWT). Electroencephalogr Clin Neurophysiol 103:554-62
Mitler, M M; Hajdukovic, R; Erman, M K (1993) Treatment of narcolepsy with methamphetamine. Sleep 16:306-17
Sangal, R B; Thomas, L; Mitler, M M (1992) Disorders of excessive sleepiness. Treatment improves ability to stay awake but does not reduce sleepiness. Chest 102:699-703
Sangal, R B; Thomas, L; Mitler, M M (1992) Maintenance of wakefulness test and multiple sleep latency test. Measurement of different abilities in patients with sleep disorders. Chest 101:898-902
Poceta, J S; Timms, R M; Jeong, D U et al. (1992) Maintenance of wakefulness test in obstructive sleep apnea syndrome. Chest 101:893-7
Mitler, M M; Hajdukovic, R (1991) Relative efficacy of drugs for the treatment of sleepiness in narcolepsy. Sleep 14:218-20
Mitler, M M; Hajdukovic, R; Erman, M et al. (1990) Narcolepsy. J Clin Neurophysiol 7:93-118
Mitler, M M; Dawson, A; Henriksen, S J et al. (1988) Bedtime ethanol increases resistance of upper airways and produces sleep apneas in asymptomatic snorers. Alcohol Clin Exp Res 12:801-5
Rubin, R L; Hajdukovich, R M; Mitler, M M (1988) HLA-DR2 association with excessive somnolence in narcolepsy does not generalize to sleep apnea and is not accompanied by systemic autoimmune abnormalities. Clin Immunol Immunopathol 49:149-58
Mitler, M M; Hajdukovic, R M; Shafor, R et al. (1987) When people die. Cause of death versus time of death. Am J Med 82:266-74

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