This study will investigate some of the physiological properties of the larynx which are affected by different neurological disorders, and relate them to acoustic and perceptual measures of the sounds produced. The phonation of normal individuals and patients with Parkinson's disease, the ataxias, hyperkinetic movement disorders, unilateral superior nerve paralysis, unilateral recurrent nerve paralysis, and unilateral vagal nerve paralysis will be examined. The physiological properties to be investigated include laryngeal configuration as observed through fiberoptic techniques, glottal area and vocal fold contact area as provided by glottography, and aerodynamic measures of glottal air flow and estimated sub-glottal air pressure. The acoustic analyses include measures of period-to-period perturbation in duration and amplitude (jitter and shimmer), spectral balance such as the energy in the first formant compared to that in the fundamental, and measures of signal vs. noise. Perceptual measures involve the rating of harshness, breathiness, strained quality, and instability. The major goals of this project include a detailed description of vocal dysfunction associated with various types of neurological impairment, the understanding of the interrelationship of the measurement techniques employed, and the assessment of these techniques for their clinical application in the diagnosis of neurogenic voice disorders. The data will also be helpful in the understanding of the normal neuromotor organization of laryngeal function during voice production.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS020707-02
Application #
3401261
Study Section
Communication Sciences and Disorders (CMS)
Project Start
1984-04-01
Project End
1987-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Tran, Q T; Berke, G S; Gerratt, B R et al. (1993) Measurement of Young's modulus in the in vivo human vocal folds. Ann Otol Rhinol Laryngol 102:584-91
Kreiman, J; Gerratt, B R; Precoda, K et al. (1992) Individual differences in voice quality perception. J Speech Hear Res 35:512-20
Shindo, M L; Hanson, D G (1990) Geriatric voice and laryngeal dysfunction. Otolaryngol Clin North Am 23:1035-44
Hanson, D G; Gerratt, B R; Berke, G S (1990) Frequency, intensity, and target matching effects on photoglottographic measures of open quotient and speed quotient. J Speech Hear Res 33:45-50
Berke, G S; Hanson, D G; Gerratt, B R et al. (1990) The effect of air flow and medial adductory compression on vocal efficiency and glottal vibration. Otolaryngol Head Neck Surg 102:212-8
Kreiman, J; Gerratt, B R; Precoda, K (1990) Listener experience and perception of voice quality. J Speech Hear Res 33:103-15
Ward, P H; Hanson, D G; Gerratt, B R et al. (1989) Current and future horizons in laryngeal and voice research. Ann Otol Rhinol Laryngol 98:145-52
Berke, G S; Moore, D M; Gerratt, B R et al. (1989) The effect of recurrent laryngeal nerve stimulation on phonation in an in vivo canine model. Laryngoscope 99:977-82
Gerratt, B R; Hanson, D G; Berke, G S (1988) Laryngeal configuration associated with glottography. Am J Otolaryngol 9:173-9
Hanson, D G; Gerratt, B R; Karin, R R et al. (1988) Glottographic measures of vocal fold vibration: an examination of laryngeal paralysis. Laryngoscope 98:541-9