We propose co complete the neurodevelopmental assessment at age 2 years of the 922 survivors of a unique cohort of 1,105 births under 2000g enrolled between 1984 and 1987 in a multi-center. geographically based study of the causes and consequences of neonatal brain hemorrhage. Current funding will only allow us to complete approximately 54% of the assessments, and a very partial analysis of those data that have been collected. Hemorrhage was ascertained through systematic, timed cranial ultrasound screening of all enrolled infants at 4 hours, 24 hours, and 7 days postnatally. Data were collected for all infants on pregnancy complications, labor and delivery abnormalities, and neonatal course (in intervals corresponding to the timed ultrasound to allow analysis by temporal sequence). A maternal postpartum interview - covering factors such as smoking, alcohol consumption, illnesses, reproductive history and antenatal was obtained from 78% of the study population. A major objective of this study is to use this extensive prenatal and perinatal data set to analyze the antecedents of neonatal brain hemorrhage. Follow-up (blind to birth history) consists of examinations of the infant's neurological status, hearing and vision, and assessments of cognition, language and behavior. An assessment of maternal psychopathology is obtained at two years, and maternal measures of stress and attitudes towards the infant are obtained both at birth and at two years. Our overall goal is to link prenatal and perinatal exposures to ultrasonographic findings, and to link these findings in turn to rates of neurodevelopmental impairment at age two.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS020713-07
Application #
3401270
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1984-04-01
Project End
1991-03-31
Budget Start
1989-08-01
Budget End
1990-03-31
Support Year
7
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Michigan State University
Department
Type
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Korzeniewski, Steven J; Feldman, Judith F; Lorenz, John M et al. (2016) Persistence of Cerebral Palsy Diagnosis: Assessment of a Low-Birth-Weight Cohort at Ages 2, 6, and 9 Years. J Child Neurol 31:461-7
Korzeniewski, Steven J; Pinto-Martin, Jennifer A; Whitaker, Agnes H et al. (2013) Association between transient hypothyroxinaemia of prematurity and adult autism spectrum disorder in a low-birthweight cohort: an exploratory study. Paediatr Perinat Epidemiol 27:182-7
Whitaker, Agnes H; Feldman, Judith F; Lorenz, John M et al. (2011) Neonatal head ultrasound abnormalities in preterm infants and adolescent psychiatric disorders. Arch Gen Psychiatry 68:742-52
Lorenz, John M; Whitaker, Agnes H; Feldman, Judith F et al. (2009) Indices of body and brain size at birth and at the age of 2 years: relations to cognitive outcome at the age of 16 years in low birth weight infants. J Dev Behav Pediatr 30:535-43
Blond, Anna I; Feldman, Judith F; Lorenz, John M et al. (2008) Eating attitudes and weight concerns in female low birth weight adolescents. Int J Eat Disord 41:573-5
Weinberger, B; Anwar, M; Hegyi, T et al. (2000) Antecedents and neonatal consequences of low Apgar scores in preterm newborns: a population study. Arch Pediatr Adolesc Med 154:294-300
Pinto-Martin, J A; Whitaker, A H; Feldman, J F et al. (1999) Relation of cranial ultrasound abnormalities in low-birthweight infants to motor or cognitive performance at ages 2, 6, and 9 years. Dev Med Child Neurol 41:826-33
Hegyi, T; Carbone, T; Anwar, M et al. (1998) The apgar score and its components in the preterm infant. Pediatrics 101:77-81
Paneth, N; Jetton, J; Pinto-Martin, J et al. (1997) Magnesium sulfate in labor and risk of neonatal brain lesions and cerebral palsy in low birth weight infants. The Neonatal Brain Hemorrhage Study Analysis Group. Pediatrics 99:E1
Reuss, M L; Paneth, N; Lorenz, J M et al. (1997) Correlates of low thyroxine values at newborn screening among infants born before 32 weeks gestation. Early Hum Dev 47:223-33

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