During the first year of the grant with a new 7-channel magnetometer we have made substantial progress in all 5 steps of the proposed research. We plan to complete the goals of the original 3 year research proposal within the 2 years awarded on the grant. We have: (1) modeled forward and inverse dipole solutions in MEG, EEG, and cortical EEG (ECoG) with goodness of fit measures and residuals; (2) modeled multiple moving dipole solutions in MEG; (3) localized the central fissure close to hand area of primary sensory cortex in 4 patients on MEG, EEG, and ECoG with moving dipole solutions, with localization errors of 4 to 6mm, verified by cortical stimulations; (4) recorded deep spikes on MEG; (5) mapped simultaneous, spontaneous MEG and ECoG of human interictal spikes; (6) verified MEG seizure localization within 1-1.5 cm by subdural recordings; (7) mapped simultaneous, spontaneous MEG and EEG of human partial seizures with dipolar patterns; and (8) implemented a 48 channel recording system for simultaneous MEG, EEG, and ECoG recording. During the final second year of the grant, we will complete all steps, mapping and localizing the center interictal spikes and seizures in multichannel MEG, EEG, and ECoG. The temporary use of a magnetically shielded room has been essential to systematic completion of steps 4 and 5. In this renewal, we propose extension of the research to more accurate epileptic source identification in a magnetically shielded room. The severe magnetic noise which has developed in our unshielded hospital environment markedly limits the natural extension of research into promising areas, developed at Reed and proved capable of study. A multichannel magnetometer in a shielded environment is essential to the systematic study of the spatiotemporal structure of simultaneous MEG, EEG and cortical EEG of the spontaneous and averaged human interictal spike and seizure. In this renewal, we request funds for salary for essential personnel and for a magnetically shielded room which we have tested during the last 2 months and the essential nature of which is shown in the progress report. We want to continue systematic investigation of MEG, comparison of MEG and EEG, and integrated use of their complementary information to identify intracranial current sources in a large number of patients to achieve statistical numbers. Funds are requested for essential consulting collaboration with Dr. Terrance Darcey of Yale University School of Medicine, New Haven, Connecticut, in MEG, EEG, and ECoG modeling. We have already obtained: (1) 39% of required funds for new equipment and (2) 36% of required funds for personnel from other sources, and those are exhausted. The funds requested here are the minimum essential to continue systematic research of the magnetic field of the human epileptic focus in a statistical number of patients.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
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Neurology A Study Section (NEUA)
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University of California Los Angeles
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Sutherling, W W; Mamelak, A N; Thyerlei, D et al. (2008) Influence of magnetic source imaging for planning intracranial EEG in epilepsy. Neurology 71:990-6
Merrifield, Warren S; Simos, Panagiotis G; Papanicolaou, Andrew C et al. (2007) Hemispheric language dominance in magnetoencephalography: sensitivity, specificity, and data reduction techniques. Epilepsy Behav 10:120-8
Merrifield, Warren S; Sutherling, William W; Mamelak, Adam N (2007) Statistical parameters of epileptiform brain activity differentiate frontal and temporal lobe patients. Epilepsy Res 74:74-8
Wu, J Y; Sutherling, W W; Koh, S et al. (2006) Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex. Neurology 66:1270-2
Ossadtchi, A; Mosher, J C; Sutherling, W W et al. (2005) Hidden Markov modelling of spike propagation from interictal MEG data. Phys Med Biol 50:3447-69
Ossadtchi, A; Baillet, S; Mosher, J C et al. (2004) Automated interictal spike detection and source localization in magnetoencephalography using independent components analysis and spatio-temporal clustering. Clin Neurophysiol 115:508-22
Mamelak, Adam N; Lopez, Nancy; Akhtari, Massoud et al. (2002) Magnetoencephalography-directed surgery in patients with neocortical epilepsy. J Neurosurg 97:865-73
Akhtari, M; Bryant, H C; Mamelak, A N et al. (2002) Conductivities of three-layer live human skull. Brain Topogr 14:151-67
Sutherling, W W; Akhtari, M; Mamelak, A N et al. (2001) Dipole localization of human induced focal afterdischarge seizure in simultaneous magnetoencephalography and electrocorticography. Brain Topogr 14:101-16
Akhtari, M; Bryant, H C; Mamelak, A N et al. (2000) Conductivities of three-layer human skull. Brain Topogr 13:29-42

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