Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS020978-06
Application #
3401660
Study Section
Neurology C Study Section (NEUC)
Project Start
1983-12-01
Project End
1989-07-31
Budget Start
1988-12-01
Budget End
1989-07-31
Support Year
6
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Yarom, M; Tang, X W; Wu, E et al. (1998) Identification of inosine as an endogenous modulator for the benzodiazepine binding site of the GABAA receptors. J Biomed Sci 5:274-80
Wu, J Y; Tang, X W; Schloss, J V et al. (1998) Regulation of taurine biosynthesis and its physiological significance in the brain. Adv Exp Med Biol 442:339-45
Tang, X W; Hsu, C C; Schloss, J V et al. (1997) Protein phosphorylation and taurine biosynthesis in vivo and in vitro. J Neurosci 17:6947-51
Tang, X W; Deupree, D L; Sun, Y et al. (1996) Biphasic effect of taurine on excitatory amino acid-induced neurotoxicity. Adv Exp Med Biol 403:499-505
Deupree, D L; Tang, X W; Yarom, M et al. (1996) Studies of NMDA- and non-NMDA-mediated neurotoxicity in cultured neurons. Neurochem Int 29:255-61
Bao, J; Cheung, W Y; Wu, J Y (1995) Brain L-glutamate decarboxylase. Inhibition by phosphorylation and activation by dephosphorylation. J Biol Chem 270:6464-7
Lee, Y H; Bhattacharyya, A; Tang, X W et al. (1995) Purification and characterization of a low molecular weight endogenous glutamate binding inhibitor (LGBI) in porcine brain. J Neurosci Res 40:797-806
Wu, J Y; Lin, C T; Johansen, F F et al. (1994) Taurine neurons in rat hippocampal formation are relatively inert to cerebral ischemia. Adv Exp Med Biol 359:289-98
Nathan, B; Bao, J; Hsu, C C et al. (1994) An integral membrane protein form of brain L-glutamate decarboxylase: purification, characterization and its relationship to insulin-dependent diabetes mellitus. Brain Res 642:297-302
Tsai, L H; Tsai, W; Wu, J Y (1994) Effect of L-glutamic acid on acid secretion and immunohistochemical localization of glutamatergic neurons in the rat stomach. J Neurosci Res 38:188-95

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