Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS021313-02
Application #
3402320
Study Section
Experimental Therapeutics Subcommittee 2 (ET)
Project Start
1985-12-01
Project End
1988-11-30
Budget Start
1986-12-01
Budget End
1988-11-30
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
McVicar, D W; Li, F; McCrady, C W et al. (1991) A comparison of serum-free media for the support of in vitro mitogen-induced blastogenic expansion of cytolytic lymphocytes. Cytotechnology 6:105-13
Merchant, R E; Ellison, M D; Young, H F (1990) Immunotherapy for malignant glioma using human recombinant interleukin-2 and activated autologous lymphocytes. A review of pre-clinical and clinical investigations. J Neurooncol 8:173-88
Watts, R G; Wright, J L; Atkinson, L L et al. (1989) Histopathological and blood-brain barrier changes in rats induced by an intracerebral injection of human recombinant interleukin 2. Neurosurgery 25:202-8
Grant, A J; Merchant, R E; Hall, R E (1989) Interleukin-2 modulates the expression of lymphocyte function-associated antigen-one (LFA-1) and p150,95 during the generation of lymphokine-activated killer (LAK) cells. Immunology 66:117-24
Atkinson, L L; Merchant, R E; Ghatak, N R et al. (1989) Sterile abscesses in glioma patients treated by intraparenchymal injection of lymphokine-activated killer cells and recombinant interleukin-2: case reports. Neurosurgery 25:805-10
McVicar, D W; Merchant, R E; Merchant, L H et al. (1989) Corticosteroids inhibit the generation of lymphokine-activated killer activity in vitro. Cancer Immunol Immunother 29:211-8
Merchant, R E; Merchant, L H; Cook, S H et al. (1988) Intralesional infusion of lymphokine-activated killer (LAK) cells and recombinant interleukin-2 (rIL-2) for the treatment of patients with malignant brain tumor. Neurosurgery 23:725-32
Merchant, R E; Grant, A J; Merchant, L H et al. (1988) Adoptive immunotherapy for recurrent glioblastoma multiforme using lymphokine activated killer cells and recombinant interleukin-2. Cancer 62:665-71
McCrady, C W; Li, F; Grant, A J et al. (1988) Alteration of human lymphokine-activated killer cell activity by manipulation of protein kinase C and cytosolic Ca2+. Cancer Res 48:635-40