The sound evoked potentials that can be recorded from the scalp are becoming of increasing importance in the clinical diagnosis of various diseases affecting the central nervous system such as tumors and multiple sclerosis. In particular, the so-called short latency components (brainstem auditory evoked potentials, BSEP) have proven to be very useful in making such diagnoses. The use of this method in precise site-of-lesion testing is, however, hampered by uncertainty as to the exact location of the neural generators of the various components of the response.
The aim of this study is to obtain a better understainding of the sources of the farfield electrical events that can be recorded from the scalp during the first 10 msec after the onset of a transient sound and to identify the neural generators of these potentials. This will be done through intracranial recordings in humans during neurosurgical operations and in animal experiments. Selective recordings from different brain nuclei will be made in both the human and animal experiments. The likelihood of a certain nerve tract or nucleus being the generator of certain parts of the scalp-recorded BSEP will be studied by determining the amplitude of the response and the anatomical extension of the generator. Experiments will be performed in baboons where the effect of pulsatile pressure on different parts of the auditory nervous system will be studied using implantable balloons. The dependence of the response on different types of stimuli will be explored in order to find optimal stimuli for different types of studies. A better understanding of the origin of these potentials and their dependence on stimulus parameters will increase the cllnical value of this test method and broaden its use in differential diagnosis of disorders afflicting the auditory nervous system.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS021378-04
Application #
3402478
Study Section
Neurology A Study Section (NEUA)
Project Start
1984-02-01
Project End
1989-01-31
Budget Start
1987-02-01
Budget End
1988-01-31
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Brandon, Marty C; Wallace, Douglas C; Baldi, Pierre (2009) Data structures and compression algorithms for genomic sequence data. Bioinformatics 25:1731-8
Moller, A R (1993) Late waves in the response recorded from the intracranial portion of the auditory nerve in humans. Ann Otol Rhinol Laryngol 102:945-53
Schmid, U D; Moller, A R; Schmid, J (1992) The excitation site of the trigeminal nerve to transcranial magnetic stimulation varies and lies proximal or distal to the foramen ovale: an intraoperative electrophysiological study in man. Neurosci Lett 141:265-8
Schmid, U D; Moller, A R; Schmid, J (1991) Transcranial magnetic stimulation excites the labyrinthine segment of the facial nerve: an intraoperative electrophysiological study in man. Neurosci Lett 124:273-6
Moller, A R; Moller, M B; Jannetta, P J et al. (1991) Auditory nerve compound action potentials and brain stem auditory evoked potentials in patients with various degrees of hearing loss. Ann Otol Rhinol Laryngol 100:488-95
Moller, A R; Jho, H D (1991) Effect of high-frequency hearing loss on compound action potentials recorded from the intracranial portion of the human eighth nerve. Hear Res 55:9-23
Moller, A R; Jho, H D (1991) Compound action potentials recorded from the intracranial portion of the auditory nerve in man: effects of stimulus intensity and polarity. Audiology 30:142-63
Moller, M B; Moller, A R (1990) Vascular compression syndrome of the eighth nerve. Clinical correlations and surgical findings. Neurol Clin 8:421-39
Moller, A R; Jho, H D (1990) Late components in the compound action potentials (CAP) recorded from the intracranial portion of the human eighth nerve. Hear Res 45:75-86
Moller, A R; Moller, M B (1989) Does intraoperative monitoring of auditory evoked potentials reduce incidence of hearing loss as a complication of microvascular decompression of cranial nerves? Neurosurgery 24:257-63

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