Abstract

Conventional and unconventional virus-like agents establish persistent infections in the CNS of man and animals and may play a role in chronic degenerative diseases such as multiple sclerosis (MS) and Alzheimer's disease (AD). The major objective of this proposal is to determine with what frequency viral genes are deposited in the human CNS and the relationship of such a residue of infections early in life to MS and AD. The studies will continue to depend on refined and sensitive methods of in situ hybridization which are capable of detecting a single copy of viral genome.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS021580-08
Application #
3402841
Study Section
Virology Study Section (VR)
Project Start
1984-07-01
Project End
1992-06-30
Budget Start
1991-07-01
Budget End
1992-06-30
Support Year
8
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Deatly, A M; Haase, A T; Fewster, P H et al. (1990) Human herpes virus infections and Alzheimer's disease. Neuropathol Appl Neurobiol 16:213-23
Haase, A T; Retzel, E F; Staskus, K A (1990) Amplification and detection of lentiviral DNA inside cells. Proc Natl Acad Sci U S A 87:4971-5