Abstract

This project proposes to continue the long term objective of studying the temporal bone histopathology in specific and general disorders with overt or possible cochlear and/or vestibular disturbance. Hearing acuity of hospitalized patients will be monitored by the use of conventional audiometry. Vestibular and electrophysiologic tests will be available in most cases. Temporal bones and brains of thoroughly evaluated patients will be removed at the time of autopsy and then processed for light microscopy examination. The cochlear and vestibular sensory cells and the first order neurons innervating these structures will be quantitatively evaluated. Similarly, a quantitative study of cell population in the primary auditory nuclei will be carried out. Correlation will be sought between the histopathologic findings in human temporal bones with the patient's history, results of auditory and vestibular studies and therapy. These studies will lead to a better understanding of cochleo-vestibular diseases and possibly to more adequate clinical preventive and therapeutic measures.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS022042-04
Application #
3403939
Study Section
Hearing Research Study Section (HAR)
Project Start
1985-05-01
Project End
1990-04-30
Budget Start
1988-05-01
Budget End
1989-04-30
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Kohut, R I; Hinojosa, R; Ryu, J H (1991) The histologic characteristics of the core of the fissula ante fenestram. Acta Otolaryngol Suppl 481:158-62
Green Jr, J D; Marion, M S; Hinojosa, R (1991) Labyrinthitis ossificans: histopathologic consideration for cochlear implantation. Otolaryngol Head Neck Surg 104:320-6
Dayal, V S; Hinojosa, R; Amenta 3rd, C A et al. (1990) Surgical inferences from study of temporal bones with glomus jugulare tumor. Otolaryngol Head Neck Surg 102:690-7
Hinojosa, R; Kohut, R I (1990) Clinical diagnosis of anterior inferior cerebellar artery thrombosis. Autopsy and temporal bone histopathologic study. Ann Otol Rhinol Laryngol 99:261-72
Green Jr, J D; Marion, M S; Erickson, B J et al. (1990) Three-dimensional reconstruction of the temporal bone. Laryngoscope 100:1-4
Nelson, E G; Hinojosa, R; Dayal, V S (1989) Quantitative evaluation of sensorineural structures following stapes surgery. Am J Otolaryngol 10:13-25
Kohut, R I; Hinojosa, R; Ryu, J H (1988) Perilymphatic fistulae: a single-blind clinical histopathologic study. Adv Otorhinolaryngol 42:148-52
Hinojosa, R; Marion, M (1987) Otosclerosis and sensorineural hearing loss: a histopathologic study. Am J Otolaryngol 8:296-307
Hinojosa, R; Lerner, S A (1987) Cochlear neural degeneration without hair cell loss in two patients with aminoglycoside ototoxicity. J Infect Dis 156:449-55
Meza, G; Hinojosa, R (1987) Ontogenetic approach to cellular localization of neurotransmitters in the chick vestibule. Hear Res 28:73-85

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