Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS022116-07
Application #
3404128
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1985-04-01
Project End
1993-03-31
Budget Start
1990-11-28
Budget End
1991-03-31
Support Year
7
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Boston University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Gyenes, M; Wang, Q; Gibbs, T T et al. (1994) Phosphorylation factors control neurotransmitter and neuromodulator actions at the gamma-aminobutyric acid type A receptor. Mol Pharmacol 46:542-9
Wu, F S; Gibbs, T T; Farb, D H (1993) Dual activation of GABAA and glycine receptors by beta-alanine: inverse modulation by progesterone and 5 alpha-pregnan-3 alpha-ol-20-one. Eur J Pharmacol 246:239-46
Celentano, J J; Gyenes, M; Gibbs, T T et al. (1991) Negative modulation of the gamma-aminobutyric acid response by extracellular zinc. Mol Pharmacol 40:766-73
Wu, F S; Gibbs, T T; Farb, D H (1991) Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor. Mol Pharmacol 40:333-6
Wu, F S; Gibbs, T T; Farb, D H (1990) Inverse modulation of gamma-aminobutyric acid- and glycine-induced currents by progesterone. Mol Pharmacol 37:597-602
Borden, L A; Gibbs, T T (1990) Flunitrazepam photoaffinity labeling of the GABA(A) receptor reduces inhibition of [3H]Ro15-4513 binding by GABA. Eur J Pharmacol 188:391-7
Roca, D J; Rozenberg, I; Farrant, M et al. (1990) Chronic agonist exposure induces down-regulation and allosteric uncoupling of the gamma-aminobutyric acid/benzodiazepine receptor complex. Mol Pharmacol 37:37-43
Roca, D J; Schiller, G D; Friedman, L et al. (1990) gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines. Mol Pharmacol 37:710-9
Czajkowski, C; Farb, D H (1989) Identification of an intracellular pool of gamma-aminobutyric acidA/benzodiazepine receptors en route to the cell surface of brain neurons in culture. Mol Pharmacol 35:183-8
Czajkowski, C; Gibbs, T T; Farb, D H (1989) Transmembrane topology of the gamma-aminobutyric acidA/benzodiazepine receptor: subcellular distribution and allosteric coupling determined in situ. Mol Pharmacol 35:75-84

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