Relatively little is known regarding the neuropsychological changes associated with multiple sclerosis (MS). It is our intent to define the cognitive and affective disturbance observed in patients with this demyelinating disease. Two groups of patients, MS (N=156) and neurological controls (N=60), will be randomly selected from a large representative patient pool and matched on the basis of age, education, occupation, sex and race. All subjects will be administered a battery of cognitive and affective psychometric tests, and will undergo a neurological examination (including measures of disability), magnetic resonance (MR) imaging, an examination of activities of daily living (ADL), and an assessment of educational/vocational activities. Sixty MS patients and all control patients will be re-evaluated after a three year interval. The objectives of this project are: (1) to determine the prevalence, type and severity of cognitive and effective disturbance in a large representative sample of patients with MS, (2) to examine the natural history of cognitive and affective disturbance in MS over a three year retest interval, (3) to identify the behavioral correlates of cerebral plaques and ventricular dilatation, as identified by MR imaging, (4) to assess the effects of cognitive and affective disturbance on ADL and educational/vocational activities, (5) to develop and validate a brief screening instrument to identify MS patients with cognitive disturbance, and (6) to study the relationship between cognitive and affective disturbance in MS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS022128-04
Application #
3404154
Study Section
Neurology A Study Section (NEUA)
Project Start
1985-12-01
Project End
1990-11-30
Budget Start
1988-12-01
Budget End
1989-11-30
Support Year
4
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
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Nyenhuis, D L; Luchetta, T; Yamamoto, C et al. (1998) The development, standardization, and initial validation of the Chicago Multiscale Depression Inventory. J Pers Assess 70:386-401
Arnett, P A; Rao, S M; Grafman, J et al. (1997) Executive functions in multiple sclerosis: an analysis of temporal ordering, semantic encoding, and planning abilities. Neuropsychology 11:535-44
Rao, S M (1996) White matter disease and dementia. Brain Cogn 31:250-68
Rao, S M (1995) Neuropsychology of multiple sclerosis. Curr Opin Neurol 8:216-20
Nyenhuis, D L; Rao, S M; Zajecka, J M et al. (1995) Mood disturbance versus other symptoms of depression in multiple sclerosis. J Int Neuropsychol Soc 1:291-6
Arnett, P A; Rao, S M; Bernardin, L et al. (1994) Relationship between frontal lobe lesions and Wisconsin Card Sorting Test performance in patients with multiple sclerosis. Neurology 44:420-5
Rao, S M; Huber, S J; Bornstein, R A (1992) Emotional changes with multiple sclerosis and Parkinson's disease. J Consult Clin Psychol 60:369-78
Haughton, V M; Yetkin, F Z; Rao, S M et al. (1992) Quantitative MR in the diagnosis of multiple sclerosis. Magn Reson Med 26:71-8
Rao, S M; Leo, G J; Bernardin, L et al. (1991) Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology 41:685-91

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