Neuropeptide Y (NPY) is a newly discovered brain peptide. It has recently been shown to be a most potent orexigenic agent after central administration. It is the specific aim of this proposal to investigate the mechanism(s) by which NPY produces its stimulatory effects on consummatory behaviors and the site(s) within the central nervous system where it produces its effects. The localization of the sites of action of NPY will be accomplished by the utilization of two techniques viz. local injections and brain lesioning techniques. In the second part of this grant we will explore (i) whether the drinking accompanying NPY-induced eating is obligatory drinking secondary to the eating, (ii) whether tolerance develops to repeated injections of NPY and (iii) the relationship of NPY to norepinephrine-induced feeding. This proposal should provide new information on the role of a new central stimulator of feeding. This basic science information should prove useful in developing new approaches to the therapy of human feeding disorders. Our recent observation that NPY can reverse the anorexia of aged rats, suggests that further studies into NPY may give clues into the pathogenesis of the anorexia of aging.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS022397-02
Application #
3404705
Study Section
Biopsychology Study Section (BPO)
Project Start
1986-02-01
Project End
1988-07-31
Budget Start
1987-02-01
Budget End
1988-07-31
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Steinman, J L; Gunion, M W; Morley, J E (1994) Forebrain and hindbrain involvement of neuropeptide Y in ingestive behaviors of rats. Pharmacol Biochem Behav 47:207-14
Shinar, D; Gross, C R; Hier, D B et al. (1987) Interobserver reliability in the interpretation of computed tomographic scans of stroke patients. Arch Neurol 44:149-55
Shinar, D; Gross, C R; Bronstein, K S et al. (1987) Reliability of the activities of daily living scale and its use in telephone interview. Arch Phys Med Rehabil 68:723-8
Morley, J E (1987) Neuropeptide regulation of appetite and weight. Endocr Rev 8:256-87
Steinman, J L; Fujikawa, D G; Wasterlain, C G et al. (1987) The effects of adrenergic, opioid and pancreatic polypeptidergic compounds on feeding and other behaviors in neonatal leghorn chicks. Peptides 8:585-92
Gross, C R; Shinar, D; Mohr, J P et al. (1986) Interobserver agreement in the diagnosis of stroke type. Arch Neurol 43:893-8
Shinar, D; Gross, C R; Mohr, J P et al. (1985) Interobserver variability in the assessment of neurologic history and examination in the Stroke Data Bank. Arch Neurol 42:557-65