Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS023066-04
Application #
3406112
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1986-02-01
Project End
1990-01-31
Budget Start
1988-10-01
Budget End
1990-01-31
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Virginia Polytechnic Institute and State University
Department
Type
Schools of Arts and Sciences
DUNS #
003137015
City
Blacksburg
State
VA
Country
United States
Zip Code
24060

  Publications

Rollema, H; Skolnik, M; D'Engelbronner, J et al. (1994) MPP(+)-like neurotoxicity of a pyridinium metabolite derived from haloperidol: in vivo microdialysis and in vitro mitochondrial studies. J Pharmacol Exp Ther 268:380-7
Subramanyam, B; Rollema, H; Woolf, T et al. (1990) Identification of a potentially neurotoxic pyridinium metabolite of haloperidol in rats. Biochem Biophys Res Commun 166:238-44
Ottoboni, S; Carlson, T J; Trager, W F et al. (1990) Studies on the cytochrome P-450 catalyzed ring alpha-carbon oxidation of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Chem Res Toxicol 3:423-7
Rollema, H; Johnson, E A; Booth, R G et al. (1990) In vivo intracerebral microdialysis studies in rats of MPP+ analogues and related charged species. J Med Chem 33:2221-30
Naiman, N; Rollema, H; Johnson, E et al. (1990) Studies on 4-benzyl-1-methyl-1,2,3,6-tetrahydropyridine, a nonneurotoxic analogue of the parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Chem Res Toxicol 3:133-8
Johnson, E A; Wu, E Y; Rollema, H et al. (1989) 1-methyl-4-phenylpyridinium (MPP+) analogs: in vivo neurotoxicity and inhibition of striatal synaptosomal dopamine uptake. Eur J Pharmacol 166:65-74
Youngster, S K; McKeown, K A; Jin, Y Z et al. (1989) Oxidation of analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by monoamine oxidases A and B and the inhibition of monoamine oxidases by the oxidation products. J Neurochem 53:1837-42
Booth, R G; Trevor, A; Singer, T P et al. (1989) Studies on semirigid tricyclic analogues of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Med Chem 32:473-7
Hammock, B D; Beale, A M; Work, T et al. (1989) A sheep model for MPTP induced Parkinson-like symptoms. Life Sci 45:1601-8
Booth, R G; Castagnoli Jr, N; Rollema, H (1989) Intracerebral microdialysis neurotoxicity studies of quinoline and isoquinoline derivatives related to MPTP/MPP+. Neurosci Lett 100:306-12

Showing the most recent 10 out of 26 publications