Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS023320-01
Application #
3406624
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1985-04-01
Project End
1988-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Type
Overall Medical
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Brady, Scott T; Morfini, Gerardo A (2017) Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases. Neurobiol Dis 105:273-282
Moreno, H; Morfini, G; Buitrago, L et al. (2016) Tau pathology-mediated presynaptic dysfunction. Neuroscience 325:30-8
Tiernan, Chelsea T; Combs, Benjamin; Cox, Kristine et al. (2016) Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. Exp Neurol 283:318-29
Song, Yuyu; Kang, Minsu; Morfini, Gerardo et al. (2016) Fast axonal transport in isolated axoplasm from the squid giant axon. Methods Cell Biol 131:331-48
Kang, Minsu; Baker, Lisa; Song, Yuyu et al. (2016) Biochemical analysis of axon-specific phosphorylation events using isolated squid axoplasms. Methods Cell Biol 131:199-216
Gatto, Rodolfo G; Chu, Yaping; Ye, Allen Q et al. (2015) Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease. Hum Mol Genet 24:5285-98
Song, Yuyu; Brady, Scott T (2015) Post-translational modifications of tubulin: pathways to functional diversity of microtubules. Trends Cell Biol 25:125-36
Song, Yuyu; Kirkpatrick, Laura L; Schilling, Alexander B et al. (2013) Transglutaminase and polyamination of tubulin: posttranslational modification for stabilizing axonal microtubules. Neuron 78:109-23
Morfini, Gerardo A; Bosco, Daryl A; Brown, Hannah et al. (2013) Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase. PLoS One 8:e65235
Kanaan, Nicholas M; Morfini, Gerardo; Pigino, Gustavo et al. (2012) Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport. Neurobiol Aging 33:826.e15-30

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