Abstract

Peripheral sensory nerve terminals appear more susceptible than their motor counterparts to the neurotoxic effects of certain agents. A lesion in the spinal cord termination of these nerves, corresponding to that in the peripheral terminals, would result in incorrect integration of proprioceptive information at spinal synapses and thus compound the peripheral defect. Primary afferent terminal function will be investigated in cats with neuropathies included by acrylamide or doxorubicin. Specifically, synapses subserving segmental reflexes and the cells of origin of the dorsal spinocerebellar tracts will be electrophysiologically evaluated. These data will be correlated with those with morphological studies in an attempt to ascertain the contribution of spinal cord defects make to the clinical signs of the peripheral neuropathies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS023325-04
Application #
3406654
Study Section
Toxicology Study Section (TOX)
Project Start
1985-07-01
Project End
1992-12-31
Budget Start
1988-01-01
Budget End
1988-12-31
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Rutgers University
Department
Type
Schools of Pharmacy
DUNS #
038633251
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901

  Publications

Monks, T J; Ghersi-Egea, J F; Philbert, M et al. (1999) Symposium overview: the role of glutathione in neuroprotection and neurotoxicity. Toxicol Sci 51:161-77
Kita, T; Philbert, M A; Wagner, G C et al. (1998) Methamphetamine-induced modification of dopamine metabolism in cultured striatal astrocytes. Pharmacol Toxicol 83:36-9
Philbert, M A; Beiswanger, C M; Manson, M M et al. (1995) Glutathione S-transferases and gamma-glutamyl transpeptidase in the rat nervous systems: a basis for differential susceptibility to neurotoxicants. Neurotoxicology 16:349-62
Beiswanger, C M; Diegmann, M H; Novak, R F et al. (1995) Developmental changes in the cellular distribution of glutathione and glutathione S-transferases in the murine nervous system. Neurotoxicology 16:425-40
Kita, T; Wagner, G C; Philbert, M A et al. (1995) Effects of pargyline and pyrogallol on the methamphetamine-induced dopamine depletion. Mol Chem Neuropathol 24:31-41
Lowndes, H E; Beiswanger, C M; Philbert, M A et al. (1994) Substrates for neural metabolism of xenobiotics in adult and developing brain. Neurotoxicology 15:61-73
Beiswanger, C M; Roscoe-Graessle, T L; Zerbe, N et al. (1993) 3-Acetylpyridine-induced degeneration in the dorsal root ganglia: involvement of small diameter neurons and influence of axotomy. Neuropathol Appl Neurobiol 19:164-72
Graff, R D; Philbert, M A; Lowndes, H E et al. (1993) The effect of glutathione depletion on methyl mercury-induced microtubule disassembly in cultured embryonal carcinoma cells. Toxicol Appl Pharmacol 120:20-8
Beiswanger, C M; Mandella, R D; Graessle, T R et al. (1993) Synergistic neurotoxic effects of styrene oxide and acrylamide: glutathione-independent necrosis of cerebellar granule cells. Toxicol Appl Pharmacol 118:233-44
Delio, D A; Fiori, M G; Lowndes, H E (1992) Motor unit function during evolution of proximal axonal swellings. J Neurol Sci 109:30-40

Showing the most recent 10 out of 21 publications