Abstract

This research proposal is a re-submission of a research project that was submitted as a competitive renewal. The long-term objective of this research proposal is to evaluate and understand potential pharmacotherapies for acute cerebral ischemia so that appropriate drugs might be tested which will reduce or prevent calcium entry into neurons or its consequences. Therapies that will be directed at this will include selected calcium channel blockers, competitive and non-competitive glutamate antagonists, phospholipase antagonists, and possibly newer agents which may act on glycine or sigma sites. Outcome measures will include mortality, light microscopic measurement of ischemic damage, and learning ability. Mechanisms of action of each pharmacotherapy will be determined by cerebral blood flow, immunocytochemical localization and quantitation of calcium calmodulin binding and assessment of CaM-kinase II activity. The second major goal of this research is to expand previous studies of calcium calmodulin binding after global ischemia to better understand calcium activated events in determining irreversible neuronal injury. Studies will be designed to correlate calcium calmodulin binding studies with CaM Kinase II activity and explore the behavior of this kinase after various ischemic intervals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS023979-06
Application #
2265034
Study Section
Neurology A Study Section (NEUA)
Project Start
1987-07-01
Project End
1994-12-31
Budget Start
1993-04-01
Budget End
1994-12-31
Support Year
6
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center Houston
Department
Neurology
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225

  Publications

Yang, Hongyan; Chopp, Michael; Weiland, Barbara et al. (2007) Sensorimotor deficits associated with brain tumor progression and tumor-induced brain plasticity mechanisms. Exp Neurol 207:357-67
Yang, Hongyan; Chopp, Michael; Zhang, Xuepeng et al. (2007) Using behavioral measurement to assess tumor progression and functional outcome after antiangiogenic treatment in mouse glioma models. Behav Brain Res 182:42-50
Yang, Hongyan; Preston, Marnie; Chopp, Michael et al. (2006) Mass-related traumatic tissue displacement and behavior: a screen for treatments that reduce [corrected] harm to bystander cells and recovery of function. J Neurotrauma 23:721-32
Yang, Hongyan; Chopp, Michael; Jiang, Feng et al. (2006) Interruption of functional recovery by the NMDA glutamate antagonist MK801 after compression of the sensorimotor cortex: implications for treatment of tumors or other mass-related brain injuries. Exp Neurol 200:262-6
Choi, Se Hoon; Woodlee, Martin T; Hong, John J et al. (2006) A simple modification of the water maze test to enhance daily detection of spatial memory in rats and mice. J Neurosci Methods 156:182-93
Yang, Hongyan; Zhang, Xuepeng; Chopp, Michael et al. (2006) Local fluorouracil chemotherapy interferes with neural and behavioral recovery after brain tumor-like mass compression. Behav Brain Res 172:80-9
Zhao, Xiurong; Liu, Shi-Jie; Zhang, Jie et al. (2005) Combining insulin-like growth factor derivatives plus caffeinol produces robust neuroprotection after stroke in rats. Stroke 36:129-34
Fleming, Sheila M; Delville, Yvon; Schallert, Timothy (2005) An intermittent, controlled-rate, slow progressive degeneration model of Parkinson's disease: antiparkinson effects of Sinemet and protective effects of methylphenidate. Behav Brain Res 156:201-13
Zhao, Xiurong; Aronowski, Jaroslaw; Liu, Shi-Jie et al. (2005) Wheel-running modestly promotes functional recovery after a unilateral cortical lesion in rats. Behav Neurol 16:41-9
Woodlee, Martin T; Asseo-Garcia, Aloysha M; Zhao, Xiurong et al. (2005) Testing forelimb placing ""across the midline"" reveals distinct, lesion-dependent patterns of recovery in rats. Exp Neurol 191:310-7

Showing the most recent 10 out of 47 publications