Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS024401-02
Application #
3408955
Study Section
Experimental Virology Study Section (EVR)
Project Start
1987-01-01
Project End
1989-12-31
Budget Start
1988-01-01
Budget End
1988-12-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Perlman, S (1998) Pathogenesis of coronavirus-induced infections. Review of pathological and immunological aspects. Adv Exp Med Biol 440:503-13
Grzybicki, D M; Kwack, K B; Perlman, S et al. (1997) Nitric oxide synthase type II expression by different cell types in MHV-JHM encephalitis suggests distinct roles for nitric oxide in acute versus persistent virus infection. J Neuroimmunol 73:15-27
Xue, S; Perlman, S (1997) Antigen specificity of CD4 T cell response in the central nervous system of mice infected with mouse hepatitis virus. Virology 238:68-78
Pewe, L; Wu, G F; Barnett, E M et al. (1996) Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease. Immunity 5:253-62
Castro, R F; Perlman, S (1996) Differential antigen recognition by T cells from the spleen and central nervous system of coronavirus-infected mice. Virology 222:247-51
Sun, N; Perlman, S (1995) Spread of a neurotropic coronavirus to spinal cord white matter via neurons and astrocytes. J Virol 69:633-41
Castro, R F; Perlman, S (1995) CD8+ T-cell epitopes within the surface glycoprotein of a neurotropic coronavirus and correlation with pathogenicity. J Virol 69:8127-31
Sun, N; Grzybicki, D; Castro, R F et al. (1995) Activation of astrocytes in the spinal cord of mice chronically infected with a neurotropic coronavirus. Virology 213:482-93
Barnett, E M; Evans, G D; Sun, N et al. (1995) Anterograde tracing of trigeminal afferent pathways from the murine tooth pulp to cortex using herpes simplex virus type 1. J Neurosci 15:2972-84
Xue, S; Jaszewski, A; Perlman, S (1995) Identification of a CD4+ T cell epitope within the M protein of a neurotropic coronavirus. Virology 208:173-9

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