Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS024782-03
Application #
3409675
Study Section
Neurology A Study Section (NEUA)
Project Start
1988-12-01
Project End
1991-03-31
Budget Start
1990-12-01
Budget End
1991-03-31
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Lee, K S; Lowenkopf, T (1993) Endogenous adenosine delays the onset of hypoxic depolarization in the rat hippocampus in vitro via an action at A1 receptors. Brain Res 609:313-5
Yamamoto, H; Fukunaga, K; Lee, K et al. (1992) Ischemia-induced loss of brain calcium/calmodulin-dependent protein kinase II. J Neurochem 58:1110-7
Arai, A; Vanderklish, P; Kessler, M et al. (1991) A brief period of hypoxia causes proteolysis of cytoskeletal proteins in hippocampal slices. Brain Res 555:276-80
Lee, K S; Frank, S; Vanderklish, P et al. (1991) Inhibition of proteolysis protects hippocampal neurons from ischemia. Proc Natl Acad Sci U S A 88:7233-7
Lee, K S; Brooks, P; Lowenkopf, T (1991) Transient ischemia attenuates neuronal afterdischarges induced in the absence of synaptic transmission. Brain Res 553:171-4
Arai, A; Kessler, M; Lee, K et al. (1990) Calpain inhibitors improve the recovery of synaptic transmission from hypoxia in hippocampal slices. Brain Res 532:63-8
Seubert, P; Lee, K; Lynch, G (1989) Ischemia triggers NMDA receptor-linked cytoskeletal proteolysis in hippocampus. Brain Res 492:366-70
Lee, K S (1989) Selective neuronal vulnerability and the distribution of N-methyl-D-aspartate (NMDA) receptors. Neurobiol Aging 10:609-11;discussion 618-20