Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS024932-04
Application #
3409966
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1986-12-01
Project End
1990-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Texas Austin
Department
Type
Schools of Pharmacy
DUNS #
City
Austin
State
TX
Country
United States
Zip Code
78712
Lewis, Duane A; Dalby, Kevin N; Abell, Creed W (2004) Conserved elements of the cytochrome P-450 superfamily found in monoamine oxidase B. Neurotoxicology 25:73-8
Smith, Lisa J; Henderson, Jessica A; Abell, Creed W et al. (2004) Effects of ovarian steroids and raloxifene on proteins that synthesize, transport, and degrade serotonin in the raphe region of macaques. Neuropsychopharmacology 29:2035-45
Zhou, B P; Wu, B; Kwan, S W et al. (1998) Characterization of a highly conserved FAD-binding site in human monoamine oxidase B. J Biol Chem 273:14862-8
Kirksey, T J; Kwan, S W; Abell, C W (1998) Arginine-42 and threonine-45 are required for FAD incorporation and catalytic activity in human monoamine oxidase B. Biochemistry 37:12360-6
Shiloff, B A; Behrens, P Q; Kwan, S W et al. (1996) Monoamine oxidase B isolated from bovine liver exists as large oligomeric complexes in vitro. Eur J Biochem 242:41-50
Kwan, S W; Lewis, D A; Zhou, B P et al. (1995) Characterization of a dinucleotide-binding site in monoamine oxidase B by site-directed mutagenesis. Arch Biochem Biophys 316:385-91
Zhou, B P; Lewis, D A; Kwan, S W et al. (1995) Mutagenesis at a highly conserved tyrosine in monoamine oxidase B affects FAD incorporation and catalytic activity. Biochemistry 34:9526-31
Zhou, B P; Lewis, D A; Kwan, S W et al. (1995) Flavinylation of monoamine oxidase B. J Biol Chem 270:23653-60
Devor, E J; Cloninger, C R; Kwan, S W et al. (1993) A genetic familial study of monoamine oxidase B activity and concentration in alcoholics. Alcohol Clin Exp Res 17:263-7
Kwan, S W; Abell, C W (1992) cDNA cloning and sequencing of rat monoamine oxidase A: comparison with the human and bovine enzymes. Comp Biochem Physiol B 102:143-7

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