Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS025382-06
Application #
2265548
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1988-02-01
Project End
1994-12-31
Budget Start
1993-09-01
Budget End
1994-12-31
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Virginia
Department
Neurology
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Swerdlow, R H; Parks, J K; Miller, S W et al. (1996) Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol 40:663-71
Howell, N; Kubacka, I; Smith, R et al. (1996) Association of the mitochondrial 8344 MERRF mutation with maternally inherited spinocerebellar degeneration and Leigh disease. Neurology 46:219-22
Parker Jr, W D; Parks, J; Filley, C M et al. (1994) Electron transport chain defects in Alzheimer's disease brain. Neurology 44:1090-6
Burkhardt, C; Kelly, J P; Lim, Y H et al. (1993) Neuroleptic medications inhibit complex I of the electron transport chain. Ann Neurol 33:512-7
Bennett, M C; Diamond, D M; Stryker, S L et al. (1992) Cytochrome oxidase inhibition: a novel animal model of Alzheimer's disease. J Geriatr Psychiatry Neurol 5:93-101
Parker Jr, W D (1991) Preclinical detection of Parkinson's disease: biochemical approaches. Neurology 41:34-6;discussion 36-7
Parker Jr, W D (1991) Cytochrome oxidase deficiency in Alzheimer's disease. Ann N Y Acad Sci 640:59-64
Parker Jr, W D; Filley, C M; Parks, J K (1990) Cytochrome oxidase deficiency in Alzheimer's disease. Neurology 40:1302-3
Parker Jr, W D; Boyson, S J; Luder, A S et al. (1990) Evidence for a defect in NADH: ubiquinone oxidoreductase (complex I) in Huntington's disease. Neurology 40:1231-4
Parker Jr, W D; Boyson, S J; Parks, J K (1989) Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol 26:719-23

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