Abstract

This project will compare the effectiveness of high-dose/long- duration ACTH therapy with that of low-dose/short-duration ACTH therapy in stopping the seizures and improving the EEGs of patients who have infantile spasms. A single-blind design will be used, and approximately 60 patients with infantile spasms will be studied prospectively in a structured protocol in which response to therapy will be determined in an objective manner by utilizing long-term comprehensive EEG and video monitoring techniques previously developed in this laboratory. The two therapeutic regimens will also be compared for incidence of consequential side effects and for relapse rates. In addition, the effects of high-dose/long-duration vs low-dose/short-duration ACTH therapy on long-term outcome will be determined.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS025884-05
Application #
3411412
Study Section
Neurology A Study Section (NEUA)
Project Start
1988-04-01
Project End
1994-03-31
Budget Start
1992-04-01
Budget End
1994-03-31
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030