Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS026371-04
Application #
2265909
Study Section
Neurology A Study Section (NEUA)
Project Start
1993-05-01
Project End
1999-03-31
Budget Start
1996-05-01
Budget End
1997-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Kekelidze, T; Khait, I; Togliatti, A et al. (2001) Altered brain phosphocreatine and ATP regulation when mitochondrial creatine kinase is absent. J Neurosci Res 66:866-72
Kekelidze, T; Khait, I; Togliatti, A et al. (2000) Brain creatine kinase and creatine transporter proteins in normal and creatine-treated rabbit pups. Dev Neurosci 22:437-43
Holtzman, D; Khait, I; Mulkern, R et al. (1999) In vivo development of brain phosphocreatine in normal and creatine-treated rabbit pups. J Neurochem 73:2477-84
Kekelidze, T; Khait, I; Togliatti, A et al. (1999) Maturational changes in rabbit brain phosphocreatine and creatine kinase. Ann N Y Acad Sci 893:309-13
Holtzman, D; Brown, M; O'Gorman, E et al. (1998) Brain ATP metabolism in hypoxia resistant mice fed guanidinopropionic acid. Dev Neurosci 20:469-77
Holtzman, D; Togliatti, A; Khait, I et al. (1998) Creatine increases survival and suppresses seizures in the hypoxic immature rat. Pediatr Res 44:410-4
Holtzman, D; Mulkern, R; Meyers, R et al. (1998) In vivo phosphocreatine and ATP in piglet cerebral gray and white matter during seizures. Brain Res 783:19-27
Mulkern, R V; Chao, H; Bowers, J L et al. (1997) Multiecho approaches to spectroscopic imaging of the brain. Ann N Y Acad Sci 820:97-122
Holtzman, D; Meyers, R; Khait, I et al. (1997) Brain creatine kinase reaction rates and reactant concentrations during seizures in developing rats. Epilepsy Res 27:7-11
Chao, H; Bowers, J L; Holtzman, D et al. (1997) Multi-echo 31P spectroscopic imaging of ATP: a scan time reduction strategy. J Magn Reson Imaging 7:425-33

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