Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS026773-04
Application #
3412791
Study Section
Neurology C Study Section (NEUC)
Project Start
1988-12-01
Project End
1992-08-31
Budget Start
1991-12-01
Budget End
1992-08-31
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Sobel, R A (2000) Genetic and epigenetic influence on EAE phenotypes induced with different encephalitogenic peptides. J Neuroimmunol 108:45-52
Smith-Norowitz, T A; Sobel, R A; Mokhtarian, F (2000) B cells and antibodies in the pathogenesis of myelin injury in Semliki Forest Virus encephalomyelitis. Cell Immunol 200:27-35
Chang, T T; Jabs, C; Sobel, R A et al. (1999) Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. J Exp Med 190:733-40
Beland, J L; Sobel, R A; Adler, H et al. (1999) B cell-deficient mice have increased susceptibility to HSV-1 encephalomyelitis and mortality. J Neuroimmunol 94:122-6
Mokhtarian, F; Zhang, Z; Shi, Y et al. (1999) Molecular mimicry between a viral peptide and a myelin oligodendrocyte glycoprotein peptide induces autoimmune demyelinating disease in mice. J Neuroimmunol 95:43-54
van der Maesen, K; Hinojoza, J R; Sobel, R A (1999) Endothelial cell class II major histocompatibility complex molecule expression in stereotactic brain biopsies of patients with acute inflammatory/demyelinating conditions. J Neuropathol Exp Neurol 58:346-58
Smith, M E; van der Maesen, K; Somera, F P et al. (1998) Effects of phorbol myristate acetate (PMA) on functions of macrophages and microglia in vitro. Neurochem Res 23:427-34
Carrizosa, A M; Nicholson, L B; Farzan, M et al. (1998) Expansion by self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive environmental antigen. J Immunol 161:3307-14
Santambrogio, L; Lees, M B; Sobel, R A (1998) Altered peptide ligand modulation of experimental allergic encephalomyelitis: immune responses within the CNS. J Neuroimmunol 81:1-13
Sobel, R A; Hinojoza, J R; Maeda, A et al. (1998) Endothelial cell integrin laminin receptor expression in multiple sclerosis lesions. Am J Pathol 153:405-15

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