Magnesium and the Pathophysiology of Brain Injury

McIntosh, Tracy K.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Project (R01)
• Project #: 5R01NS026818-06
• Application #: 2266129
• Study Section: Neurology A Study Section (NEUA)
• Project Start: 1988-12-01
• Project End: 1999-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 6
• Fiscal Year: 1996

Institution

• Name: University of Pennsylvania
• Department: Surgery
• Type: Schools of Medicine
• DUNS #: 042250712
• City: Philadelphia
• State: PA
• Country: United States
• Zip Code: 19104

Publications

Tomasevic, Gregor; Raghupathi, Ramesh; Scherbel, Uwe et al. (2010) Deletion of the p53 tumor suppressor gene improves neuromotor function but does not attenuate regional neuronal cell loss following experimental brain trauma in mice. J Neurosci Res 88:3414-23

Raghupathi, Ramesh; Muir, Judith K; Fulp, Carl T et al. (2003) Acute activation of mitogen-activated protein kinases following traumatic brain injury in the rat: implications for posttraumatic cell death. Exp Neurol 183:438-48

Raghupathi, Ramesh; Strauss, Kenneth I; Zhang, Chen et al. (2003) Temporal alterations in cellular Bax:Bcl-2 ratio following traumatic brain injury in the rat. J Neurotrauma 20:421-35

Williams, S; Raghupathi, R; MacKinnon, M A et al. (2001) In situ DNA fragmentation occurs in white matter up to 12 months after head injury in man. Acta Neuropathol (Berl) 102:581-90

Shaw, K; MacKinnon, M A; Raghupathi, R et al. (2001) TUNEL-positive staining in white and grey matter after fatal head injury in man. Clin Neuropathol 20:106-12

LaPlaca, M C; Zhang, J; Raghupathi, R et al. (2001) Pharmacologic inhibition of poly(ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats. J Neurotrauma 18:369-76

Saatman, K E; Bareyre, F M; Grady, M S et al. (2001) Acute cytoskeletal alterations and cell death induced by experimental brain injury are attenuated by magnesium treatment and exacerbated by magnesium deficiency. J Neuropathol Exp Neurol 60:183-94

Laurer, H L; McIntosh, T K (2001) Pharmacologic therapy in traumatic brain injury: update on experimental treatment strategies. Curr Pharm Des 7:1505-16

Blaha, G R; Raghupathi, R; Saatman, K E et al. (2000) Brain-derived neurotrophic factor administration after traumatic brain injury in the rat does not protect against behavioral or histological deficits. Neuroscience 99:483-93

Morrison 3rd, B; Eberwine, J H; Meaney, D F et al. (2000) Traumatic injury induces differential expression of cell death genes in organotypic brain slice cultures determined by complementary DNA array hybridization. Neuroscience 96:131-9