Abstract

The possibility of quantitative measurements of deoxyhemoglobin concentrations in the neonate and adult brain depends upon picosecond pulse of phase modulation spectroscopy that determines the optical path traveled by photons exiting from the brain. Algorithms, based upon a program of milk and animal models, will be developed to permit localization of pathological states due to brain bleeding, i.e., hematomas or aneurysms. Thus, the possibility of on-radioactive, non-magnetic, non-confining studies based upon innocuous low-powered deposition near red illumination on the surface of the head is the general goal of these studies. These developments can lead to a new technology of quantitation and localization of normal and pathological levels of deoxyhemoglobin in the human brain. It is conceived that this instrument has clinical applications and safety aspects that would allow it to be used wherever needed in research and clinical studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS027346-03
Application #
3413608
Study Section
Special Emphasis Panel (SSS (G))
Project Start
1989-04-01
Project End
1993-06-30
Budget Start
1991-04-01
Budget End
1993-06-30
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University City Science Center
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Shiino, Akihiko; Matsuda, Masayuki; Chance, Britton (2002) Three-dimensional redox imaging of frozen-quenched brain and other organs. Methods Enzymol 352:475-82
Shiino, A; Haida, M; Beauvoit, B et al. (1999) Three-dimensional redox image of the normal gerbil brain. Neuroscience 91:1581-5
Shiino, A; Matsuda, M; Handa, J et al. (1998) Poor recovery of mitochondrial redox state in CA1 after transient forebrain ischemia in gerbils. Stroke 29:2421-4;discussion 2425
Chance, B; Luo, Q; Nioka, S et al. (1997) Optical investigations of physiology: a study of intrinsic and extrinsic biomedical contrast. Philos Trans R Soc Lond B Biol Sci 352:707-16
Chance, B; Mayevsky, A; Guan, B et al. (1997) Hypoxia/ischemia triggers a light scattering event in rat brain. Adv Exp Med Biol 428:457-67
Chance, B; Liu, H; Kitai, T et al. (1995) Effects of solutes on optical properties of biological materials: models, cells, and tissues. Anal Biochem 227:351-62
Benaron, D A; Kurth, C D; Steven, J M et al. (1995) Transcranial optical path length in infants by near-infrared phase-shift spectroscopy. J Clin Monit 11:109-17
Robertson, C S; Gopinath, S P; Chance, B (1995) A new application for near-infrared spectroscopy: detection of delayed intracranial hematomas after head injury. J Neurotrauma 12:591-600
Gopinath, S P; Robertson, C S; Contant, C F et al. (1995) Early detection of delayed traumatic intracranial hematomas using near-infrared spectroscopy. J Neurosurg 83:438-44
Kang, K A; Bruley, D F; Londono, J M et al. (1994) Highly scattering optical system identification via frequency response analysis of NIR-TRS spectra. Ann Biomed Eng 22:240-52

Showing the most recent 10 out of 23 publications