Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS028225-06
Application #
2266840
Study Section
Neurology A Study Section (NEUA)
Project Start
1989-09-01
Project End
1997-01-31
Budget Start
1996-04-05
Budget End
1997-01-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Henry M. Jackson Fdn for the Adv Mil/Med
Department
Type
DUNS #
City
Rockville
State
MD
Country
United States
Zip Code
20817
Sairanen, T R; Lindsberg, P J; Brenner, M et al. (2001) Differential cellular expression of tumor necrosis factor-alpha and Type I tumor necrosis factor receptor after transient global forebrain ischemia. J Neurol Sci 186:87-99
Siren, A L; McCarron, R; Wang, L et al. (2001) Proinflammatory cytokine expression contributes to brain injury provoked by chronic monocyte activation. Mol Med 7:219-29
Sairanen, T R; Lindsberg, P J; Brenner, M et al. (1997) Global forebrain ischemia results in differential cellular expression of interleukin-1beta (IL-1beta) and its receptor at mRNA and protein level. J Cereb Blood Flow Metab 17:1107-20
Liu, Y; Liu, T; McCarron, R M et al. (1996) Evidence for activation of endothelium and monocytes in hypertensive rats. Am J Physiol 270:H2125-31
Lindsberg, P J; Siren, A L; Feuerstein, G Z et al. (1995) Antagonism of neutrophil adherence in the deteriorating stroke model in rabbits. J Neurosurg 82:269-77
McCarron, R M; Wang, L; Siren, A L et al. (1994) Monocyte adhesion to cerebromicrovascular endothelial cells derived from hypertensive and normotensive rats. Am J Physiol 267:H2491-7
McCarron, R M; Doron, D A; Siren, A L et al. (1994) Agonist-stimulated release of von Willebrand factor and procoagulant factor VIII in rats with and without risk factors for stroke. Brain Res 647:265-72
Liu, Y; Jacobowitz, D M; Barone, F et al. (1994) Quantitation of perivascular monocytes and macrophages around cerebral blood vessels of hypertensive and aged rats. J Cereb Blood Flow Metab 14:348-52
Siren, A L; Liu, Y; Feuerstein, G et al. (1993) Increased release of tumor necrosis factor-alpha into the cerebrospinal fluid and peripheral circulation of aged rats. Stroke 24:880-6;discussion 887-8
Siren, A L; Heldman, E; Doron, D et al. (1992) Release of proinflammatory and prothrombotic mediators in the brain and peripheral circulation in spontaneously hypertensive and normotensive Wistar-Kyoto rats. Stroke 23:1643-50;discussion 1650-1

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