Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS028406-03
Application #
3414893
Study Section
Neurology B Subcommittee 2 (NEUB)
Project Start
1990-01-01
Project End
1992-02-29
Budget Start
1992-01-01
Budget End
1992-02-29
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Neve, R L; Valletta, J S; Li, Y et al. (1996) A comprehensive study of the spatiotemporal pattern of beta-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor. Brain Res Mol Brain Res 39:185-97
Bahr, B A; Neve, R L; Sharp, J et al. (1994) Rapid and stable gene expression in hippocampal slice cultures from a defective HSV-1 vector. Brain Res Mol Brain Res 26:277-85
Kibbey, M C; Jucker, M; Weeks, B S et al. (1993) beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin. Proc Natl Acad Sci U S A 90:10150-3
Ivins, K J; Neve, K A; Feller, D J et al. (1993) Antisense GAP-43 inhibits the evoked release of dopamine from PC12 cells. J Neurochem 60:626-33
Brandt, P; Neve, R L; Kammesheidt, A et al. (1992) Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels. J Biol Chem 267:4376-85
Brandt, P; Neve, R L (1992) Expression of plasma membrane calcium-pumping ATPase mRNAs in developing rat brain and adult brain subregions: evidence for stage-specific expression. J Neurochem 59:1566-9
Kammesheidt, A; Boyce, F M; Spanoyannis, A F et al. (1992) Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain. Proc Natl Acad Sci U S A 89:10857-61
Neve, R L; Kammesheidt, A; Hohmann, C F (1992) Brain transplants of cells expressing the carboxyl-terminal fragment of the Alzheimer amyloid protein precursor cause specific neuropathology in vivo. Proc Natl Acad Sci U S A 89:3448-52
Cox, B A; Henningsen, R A; Spanoyannis, A et al. (1992) Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors. J Neurochem 59:627-35
Kozlowski, M R; Spanoyannis, A; Manly, S P et al. (1992) The neurotoxic carboxy-terminal fragment of the Alzheimer amyloid precursor binds specifically to a neuronal cell surface molecule: pH dependence of the neurotoxicity and the binding. J Neurosci 12:1679-87

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