Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS028432-04
Application #
2266924
Study Section
Neurology A Study Section (NEUA)
Program Officer
Oliver, Eugene J
Project Start
1992-05-01
Project End
1997-08-31
Budget Start
1995-05-01
Budget End
1997-08-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Florida Agricultural and Mechanical University
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Tallahassee
State
FL
Country
United States
Zip Code
32307

  Publications

Lee, Eun-Sook; Chen, Hongtao; Hardman, Chadwick et al. (2008) Excessive S-adenosyl-L-methionine-dependent methylation increases levels of methanol, formaldehyde and formic acid in rat brain striatal homogenates: possible role in S-adenosyl-L-methionine-induced Parkinson's disease-like disorders. Life Sci 83:821-7
Lee, Eun-Sook Y; Chen, Hongtao; King, Jennifer et al. (2008) The role of 3-O-methyldopa in the side effects of L-dopa. Neurochem Res 33:401-11
Lamango, Nazarius S; Ayuk-Takem, Lambert T; Nesby, Robert et al. (2003) Inhibition mechanism of S-adenosylmethionine-induced movement deficits by prenylcysteine analogs. Pharmacol Biochem Behav 76:433-42
Zhao, Wan-Qian; Williams, Zakia; Shepherd, Kennie R et al. (2002) S-adenosyl-methionine-induced apoptosis in PC12 cells. J Neurosci Res 69:519-29
Lamango, N S; Charlton, C G (2000) Farnesyl-L-cysteine analogs block SAM-induced Parkinson's disease-like symptoms in rats. Pharmacol Biochem Behav 66:841-9
Lamango, N S; Nesby, R A; Charlton, C G (2000) Quantification of S-adenosylmethionine-induced tremors: a possible tremor model for Parkinson's disease. Pharmacol Biochem Behav 65:523-9
Liu, X X; Wilson, K; Charlton, C G (2000) Effects of L-dopa treatment on methylation in mouse brain: implications for the side effects of L-dopa. Life Sci 66:2277-88
Charlton, C G (1997) Depletion of nigrostriatal and forebrain tyrosine hydroxylase by S-adenosylmethionine: a model that may explain the occurrence of depression in Parkinson's disease. Life Sci 61:495-502
Charlton, C G; Crowell Jr, B (1995) Striatal dopamine depletion, tremors, and hypokinesia following the intracranial injection of S-adenosylmethionine: a possible role of hypermethylation in parkinsonism. Mol Chem Neuropathol 26:269-84
Charlton, C G; Mack, J (1994) Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism. Mol Neurobiol 9:149-61

Showing the most recent 10 out of 12 publications