This project aims to address the question whether the elevated levels of glutamate and other neurotransmitters that have been reported in brain following an ischemic insult are indeed important in the subsequent cascade of events leading to cell death or whether they are merely an expression of generalized energy failure. The studies will examine the temporal pattern of changes in the extracellular concentration of excitatory amino acids (EAA) and glycine following episodes of transient global ischemia in rabbits. Microdialysis will be used to obtain fine resolution measurements of regional brain tissue concentrations of these transmitter substances. The relationship between various physiological variables and pharmacological agents thought to alter neurologic outcome and the release of EEA will be analyzed. These agents will include NMDA antagonists and adenosine agonists. The results of these studies will provide a better understanding of the mechanisms of neurological injury in ischemic hypoxia and will help to resolve some of the questions regarding the therapeutic benefit of various neuroprotective agents and interventions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS029403-02
Application #
3416206
Study Section
Neurology A Study Section (NEUA)
Project Start
1991-05-01
Project End
1995-04-30
Budget Start
1992-05-01
Budget End
1993-04-30
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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Bacher, A; Kwon, J Y; Zornow, M H (1998) Effects of temperature on cerebral tissue oxygen tension, carbon dioxide tension, and pH during transient global ischemia in rabbits. Anesthesiology 88:403-9

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