The applicant proposes to compare the presence of JC virus DNA, detected by PCR, in six patient groups. These groups include patients with AIDS-associated PML, patients with PML without AIDS, HIV-positive patients without evidence of PML, patients with inflammatory disorders of the nervous system without HIV-related disease or PML, immunosuppressed patients without PML or HIV-related disease, and other neurologic controls. The applicant anticipates that these experiments will serve the broad, long-term objective of determining whether the presence of JC viral DNA, as detected by PCR in the cerebrospinal fluid (CSF) of patients, can be used as a non-invasive marker for the diagnosis of PML.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS029603-01
Application #
3416447
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1991-07-01
Project End
1993-06-30
Budget Start
1991-07-01
Budget End
1992-06-30
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905